Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1393
10
1
gregorian
2015
1
1
29
1
online
1
fulltext
en
Cervical and ocular vestibular evoked myogenic potentials in multiple sclerosis participants
Audiology
Audiology
Original Research
Original Research
<p> <strong> Background: </strong>Multiple sclerosis (MS) is a chronic neurological disease that affects brain and spinal cord. The infratentorial region contains the cerebellum and brainstem. Vestibular evoked myogenic potentials (VEMPs) are short-latency myogenic responses. Cervical vestibular evoked myogenic potential (cVEMP) is a manifestation of vestibulocolic reflex and ocular vestibular evoked myogenic potential (oVEMP) contributes to the linear vestibular–ocular reflex. The aim of this study was to evaluate cVEMP and oVEMP in MS patients with and without infratentorial plaques and compare the findings with normal controls. </p><p> <strong> Methods </strong>: In this cross-sectional study, latency and amplitude of cVEMP and oVEMP were recorded in 15 healthy females with mean age of 31.13±9.27 years, 17 female MS patients with infratentorial plaque(s) and mean age of 29.88±8.93 years, and 17 female MS patients without infratentorial plaque(s) and mean age of 30.58±8.02 years. All patients underwent a complete clinical neurological evaluation and brain MRI scanning. Simple random sampling method was used in this study and data were analyzed using one way ANOVA through SPSS v22. </p><p> <strong> Results </strong>: The latency of N1-P1 and P13 in MS participants with and without infratentorial plaques were significantly prolonged compared to normal controls (p<0.001). Additionally latency of P13-N23-N1 and P1 in MS patients with infratentorial plaques were significantly prolonged compared to patients without infratentorial plaques subjects (p<0.001). </p><p> <strong> Conclusion </strong>: Abnormality of both cVEMP and oVEMP in MS patient with infratentorial plaque are more than that of MS patient without infratentorial plaque. Recording both ocular and cervical VEMPs are appropriate electrophysiologic methods assessing the function of both ascending and descending central vestibular pathways. </p>
Multiple sclerosis, Cervical, ocular, Vestibular evoked myogenic potential, Infratentorial plaque.
35
41
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-774&slc_lang=en&sid=1
Maryam
Sadat Parsa
m.parsa1989@gmail.com
200319475328460014829
200319475328460014829
No
Department of Audiology, Faculty of rehabilitation, Tehran University of medical sciences, Tehran, Iran.
Ghassem
Mohammadkhani
mohamadkhani@tums.ac.ir
200319475328460014830
200319475328460014830
Yes
Department of Audiology, Faculty of rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
Fahimeh
Hajabolhassani
abolhassani@tums.ac.ir
200319475328460014831
200319475328460014831
No
Faculty of rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
Shohreh
Jalaee
jalaeish@sina.tums.ac.ir
200319475328460014832
200319475328460014832
No
Department of physiotherapy, Faculty of rehabilitation , Tehran University of Medical Sciences, Tehran, Iran.
Hassanali
Zakeri
gm_khani@yahoo.com
200319475328460014833
200319475328460014833
No
Tehran University Medical Sciences, Tehran, Iran.