en Anatomical Sciences Anatomical Sciences Original Research Original Research <p> <strong> Background: </strong>Toll- like receptors (TLRs) play an important role in the recognition of DAMPs and PAMPs and induction ofinflammation. Previous studies demonstrated that depression and anxiety can influence the expression levels of immune related molecules. Our previous study revealed that mRNA levels of IRAK4, TRAF3 and IRF7 were significantly decreased in chronic HBV infected (CHB) patients when compared to healthy controls. Therefore, the aim of this study was to evaluate the effects of depression and anxiety on the expression levels of these molecules in CHB patients. </p><p> <strong> Methods </strong>: Sixty CHB patients participated in this studyand filled out the standard questionnaires and the expression of IRAK4, TRAF3 and IRF7 were examined using Real-Time PCR techniques. </p><p> <strong> Results </strong>: The results of this study demonstrated that expression of IRAK4, TRAF3 and IRF7 did not differ between patients with various stages of depression and anxiety (all p>0.05). </p><p> <strong> Conclusion </strong>: According to the results, it seems that declined expression of IRAK4, TRAF3 and IRF7 inCHB patients were not related to depression and anxiety, and other factors including genetic and immunoregulatory effects of HBV may be responsible for the declined expression of these molecules. </p> Depression, Anxiety, Chronic HBV infection, IRAK4, TRAF3, IRF7. 169 173 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-793&slc_lang=en&sid=1 Mehdi Nikbakht Dastjerdi nikbakht@med.mui.ac.ir 200319475328460015641 200319475328460015641 No Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Mohammad Momeni Immunology85@yahoo.com 200319475328460015642 200319475328460015642 No Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Reza Bidaki reza.bidaki111@yahoo.com 200319475328460015643 200319475328460015643 No Department of Psychiatry, Research center for Addiction and Behavioral Sciences, ShahidSadoughi University of Medical Sciences, Yazd, Iran. Mehdi Khaleghinia m.inf088830@yahoo.com 200319475328460015644 200319475328460015644 No Kerman University of Medical Sciences, Kerman, Iran. Masoud Karimi-Googheri masoud7756@gmail.com 200319475328460015645 200319475328460015645 No Department of Immunology, Kerman University of Medical Sciences, Kerman, Iran. Mohammad Kazemi Arababadi dr.kazemi@rums.ac.ir 200319475328460015646 200319475328460015646 No Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Ahmad Shabanizadeh shebani54@yahoo.com 200319475328460015647 200319475328460015647 Yes Department of Anatomy, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.