en Pediatric Pediatric Original Research Original Research <p> <strong> Background: </strong>Proanthocyanidin is a potent bioactive antioxidant naturally occurring in grape seed and acts as reactive oxygen species (ROS) scavenger. The aim of this study was to investigate the effects of proanthocyanidinin in experimental ovarian torsion injury. </p><p> <strong> Methods </strong>: Twenty four rats were randomly divided into three groups (n=8). Group 1: the laparotomy group, group 2: ovarian torsion group, and group 3: intervention group administered proanthocyanidinin of 50 mg/kg before bilateral ovarian ischemia and reperfusion. Histologic examination and scoring was done at the end of the experiment. Statistical analyses were performed using the SPSS v. 19. </p><p> <strong> Results </strong>: Ovarian histopathologic findings of all three groups were significantly different in terms of hemorrhage (p<0.001), edema (p=0.001) and vascular dilatation (p< 0.001). Pathologic changes induced by I/R were reduced in ovaries of rats administered proanthocyanidin, in particular, hemorrhage, edema and vascular dilatation. </p><p> <strong> Conclusion </strong>: Proanthocyanidin, known as free radical scavenger and antioxidant, is protective against tissue damage induced by ischemia and/or ischemia/reperfusion in rat ovaries. </p> Proanthocyanidinin, Fertility, Ischemia Reperfusion, Ovarian torsion. 210 215 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-802&slc_lang=en&sid=1 Şule Yıldırım sule.yildirim@comu.edu.tr 200319475328460015197 200319475328460015197 Yes Department of Pediatrics, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey. Naci Topaloğlu nacitopaloglu@gmail.com 200319475328460015198 200319475328460015198 No Department of Pediatrics, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey. Mustafa Tekin mustafa5060@gmail.com 200319475328460015199 200319475328460015199 No Department of Pediatrics, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey. Adem Küçük ademkucuk81@hotmail.com 200319475328460015200 200319475328460015200 No Department of Pediatric Surgery, Düzce Atatürk State Hospital, Düzce, Turkey. Havva Erdem drhavvaerdem@hotmail.com 200319475328460015201 200319475328460015201 No Department of Pathology, Düzce University Medical Faculty, Düzce, Turkey. Mesut Erbaş benimmesut@hotmail.com 200319475328460015202 200319475328460015202 No Department of Anesthesiology, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey. Ahmet Yıldırım . ahmetyildirim@comu.edu.tr 200319475328460015203 200319475328460015203 No Department of Emergency Medicine, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey.