en Physical Therapy Physical Therapy Original Research Original Research <p>&nbsp;<strong> Background: </strong>Dyssynergic defecation is a major cause of chronic functional constipation as a common digestive complaint. We clinically evaluated the effects of biofeedback therapy on the pelvic floor motion indices through magnetic resonance (MR) defecography, quality of life and depression in patients with dyssynergic defecation.</p> <p>&nbsp;<strong> Methods </strong>: In this clinical trial study, among patients referring to the Colorectal Clinic of HazratRasoul Hospital, 22 subjects were randomly assigned into two equal groups (n=11) to receive either standard only or biofeedback and standard therapy. Dynamic changes of the pelvic floor were measured by MR defecography. During the simulated defecation, two MR defecography dynamic indices including abnormal anorectal angle change and perineal descent were measured before and after treatment. The effects of biofeedback therapy on patients&rsquo; symptoms, quality of life and severity of depression were assessed and compared with the standard therapy. Statistical analysis was carried out using independent _t-test and Mann-Whitney test.</p> <p>&nbsp;<strong> Results </strong>: Paradox index (p< 0.001), perineal descent index (p< 0.001), depression (p< 0.1), physical function (p<0.001), vitality (p< 0.001) and role emotion (p< 0.001) significantly improved in the biofeedback therapy group in contrast to the standard therapySDT group.</p> <p>&nbsp;<strong> Conclusion </strong>: Biofeedback therapy appears to be effective in improving symptoms of functional constipation and dysfunction of pelvic floor motion as well as patient&rsquo;s quality of life and depression state. MR defecography is able to show the changes in dynamic indices of the pelvic floor through biofeedback therapy.</p> Biofeedback Therapy, MR Defecography, Functional Constipation,Dyssynergic Defecation. 236 247 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-804&slc_lang=en&sid=1 Afsaneh Nikjooy afsanehnikjooy@yahoo.com 200319475328460024440 200319475328460024440 No Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran. Nader Maroufi maroufi.n@iums.ac.ir 200319475328460024441 200319475328460024441 Yes Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran. Ismaeil Ebrahimi Takamjani ebrahimi.pt@gmail.com 200319475328460024442 200319475328460024442 No Department of Physiotherapy, School of Rehabilitation, Sciences, Iran University of Medical Sciences, Tehran, Iran. Homayoun Hadizdeh Kharazi drhhh_kharazi@yahoo.com.sg 200319475328460024443 200319475328460024443 No Babak imaging Center, & Department of Radiology, RasoulAkram Hospital, Iran University of Medical Sciences, Tehran, Iran. Bahar Mahjoubi bahar1167@yahoo.com 200319475328460024444 200319475328460024444 No Department, Colorectal Research Center (CRRC) RasoulAkram Hospital, Iran University of Medical Sciences, Tehran, Iran. Rasoul Azizi razizimd@hotmail.com 200319475328460024445 200319475328460024445 No Colorectal Surgery Department, RasoulAkram Hospital, Iran University of Medical Sciences, Tehran, Iran. Hamid Haghani haghani511@yahoo.com 200319475328460024446 200319475328460024446 No School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.