Medical Journal of the Islamic Republic Of Iran

en Plasma oxysterol level in patients with coronary artery stenosis and its changes in response to the treatment with atorvastatin Cardiology Cardiology Original Research Original Research Background: Considering the increasing incidence of coronary artery stenosis and its related complications, the importance of its etiology and inconsistent reports we aimed to determine the relationship between oxysterol, serum levels and severity of coronary atherosclerosis and effect of statins on oxysterol. Methods: A total of 85 patients referred to Taleghani Hospital, Tehran, Iran during 2011-2012 with coronary artery stenosis more than 75%, as determined by angiography, participated in the current study. Their demographic information and history of smoking and taking atorvastatin was carefully recorded. Two milliliters of venous blood was obtained from each patient. The serum oxysterol level of samples was measured using the enzyme-linked immunosorbent assay (ELISA) method. Statistical analysis was performed using SPSS v.19. Results: Eighty five patients completed the study. Mean age of patients was 64.4 years 51 (60%) were male 55 (68%) had acute coronary syndrome and 30 (32%) had chronic stable angina. Mean±SD of plasma level of oxysterol was 24.8±0.2 pmol/ml. The normal range of oxysterol level was 13pmol/ml. Mean±SD of plasma oxysterol level in patients under statin therapy was 24.4±2.1 pmol/ml. In patients without receiving statins, plasma oxysterol level was 26.38±1.6pmol/ml. Conclusion: Findings of the present study indicated significant correlation between serum oxysterol and severity of coronary artery stenosis. It also demonstrated that receiving atorvastatin is associated with significant reduction of plasma oxysterol level. Coronary stenosis, Atorvastatin, Hydroxymethylglutaryl-CoA Reductase Inhibitors, An-ticholesteremic agents. 273 278 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-807&slc_lang=en&sid=1 Amir-Hamzeh Pordal 200319475328460015409 200319475328460015409 No Department of Basic Sciences, National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, ShahidBeheshti University of Medical Sciences, Tehran, Iran. Seyed Javad Hajmiresmail chancellor@iums.ac.ir 200319475328460015410 200319475328460015410 No Department of cardiology, Iran University of Medical Sciences, Tehran, Iran. Mohammad Assadpoor-Piranfar drpiranfar@yahoo.com 200319475328460015411 200319475328460015411 No Department of Cardiology, Taleghani Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran. Iran. Mehdi Hedayati hedayati@endocrine.ac.ir 200319475328460015412 200319475328460015412 No Head of Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Marjan Ajami Nutritionist80@gmail.com 200319475328460015413 200319475328460015413 Yes Department of Food and Nutrition Policy and Planning Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, ShahidBeheshti University of Medical Sciences, Tehran, Iran.