en Health Health Review Article Review Article <p> <strong> Background: </strong>Catheter ablation is widely used for treatment of atrial fibrillation. The use of fluoroscopic and non-fluoroscopic mapping systems in catheter ablation is common. This study conducted to investigate the safety and effectiveness of Navx non-fluoroscopic mapping system. </p><p> <strong> Methods </strong>: In this study, the appropriate electronic databases including Cochrane Library and Ovid Medline searched until August 2013 using free text and MeSH. Systematic reviews, health technology assessment reports in which systematic review was conducted and controlled trials with the sample size of 100 patients and more were included into the study. Results of included studies were analyzed qualitatively. </p><p> <strong> Results </strong>: Seven papers were included in this study. According to these studies, non-fluoroscopic guidance systems may reduce the exposure to radiation compared to fluoroscopic system. NavX system has minimum exposure time. Non-fluoroscopic guidance systems are safer than fluoroscopic guidance system. NavX system reduces the procedure and fluoroscopy time. There was no significant difference between two systems, NavX and Carto, based on their safety and effectiveness. </p><p> <strong> Conclusion </strong>: EnsiteNavX system is relatively safer and more effective than fluoroscopic guidance systems for treating the cardiac arrhythmia. </p> Catheter Ablation, Cardiac Arrhythmia, Systematic Review. 248 256 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-809&slc_lang=en&sid=1 Mohammadreza Mobinizadeh mobinreza@yahoo.com 200319475328460015548 200319475328460015548 No Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran, Iran. Jalal Arabloo arabloo_j@razi.tums.ac.ir 200319475328460015549 200319475328460015549 No Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Pejman Hamouzadeh pejman.hamouzadeh@gmail.com 200319475328460015550 200319475328460015550 No Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Ali Akbari Sari akbarisari@tums.ac.ir 200319475328460015551 200319475328460015551 Yes Department of Health Management and Economics, and Knowledge Utilization Research Center, Tehran University of Medical Sciences, Tehran, Iran.