en Clinical Psychology Clinical Psychology Original Research Original Research <p>Abstract </p><p>Background: Personality disorders have essential roles in developing and maintaining depressive episodes, though psychotherapies must approach both symptoms and personality problems. This study examined the efficacy of Brief Object Relations Psychotherapy on depression severity and perceived quality of life of women suffer from major depressive disorder comorbid with cluster C personality disorders. Methods: by purposive sampling method, 6 subjects which met the in/exclusion criteria, were participated in a single subject design study randomly. Interventions were arranged based on A/B with follow up design. Each subject completed Beck Depression Inventory (BDI-II) and original McGill Quality of Life Questionnaire (MQOL) every session during 3 baseline, 15 treatment and 3 follow up assessments sessions. Results: Patients totally reached 55% remission in depression severity with mean effect size 1.92 and 43% remission in perceived quality of life with mean effect size 2.08. Gains were maintained in follow up. Conclusion: The efficacy of Brief Object Relations Psychotherapy was statistically and clinically significant. Perceived quality of life reached to normal range, whereas cluster C personality disorders resistance remission from depression. </p> object relations, depression, quality of life 57 65 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-155&slc_lang=en&sid=1 Shima Shakiba shimashakibash@yahoo.com 20031947532846002073 20031947532846002073 Yes Clinical Psychology Department, University of SocialWelfare and Rehabilitation Sciences, Evin, Koodakyar Ave, Tehran, Iran Parvaneh Mohamadkhani parmohamir@yahoo.com 20031947532846002074 20031947532846002074 No Clinical Psychology Department, University of Social Welfare and Rehabilitation Sciences, Evin, Koodakyar Ave, Tehran, Iranf Abbas Poorshahbaz apourshahbaz@yahoo.com 20031947532846002075 20031947532846002075 No Clinical Psychology Department, University of Social Welfare and Rehabilitation Sciences, Evin, Koodakyar Ave, Tehran, Iran Nahale Moshtaghbidokhti nahale.moshtagh@gmail.com. 20031947532846002076 20031947532846002076 No Clinical Psychology Department, University ofSocial Welfare and Rehabilitation Sciences, Evin, Koodakyar Ave, Tehran, Iran