Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1393
10
1
gregorian
2015
1
1
29
1
online
1
fulltext
en
Effect of iron oxide nanoparticles coating type on the relationship between nanoparticles concentration and signal intensity in inver-sion recovery T1-weighted MRI
Radiology
Radiology
Original Research
Original Research
<p> <strong> Background: </strong>Ultrasmallsuperparamagnetic iron oxide (USPIO) nanoparticles are used as blood pool contrast agent for magnetic resonance angiography and perfusion imaging. Our aim in this study was to investigate the effect of the two coating types of iron oxide nanoparticles on the relationship between nanoparticles concentration and signal intensity (SI) in T1-weighted MR images. </p><p> <strong> Methods </strong>: Different concentrations of the polyethylene glycol (PEG), and carboxydextran-coated iron oxide nanoparticles were imaged using inversion recovery Turbo-FLASH (Turbo fast low-angle shot) pulse sequence with inversion times (TIs) of 300-900 ms (interval of 100 ms). The maximum non-linear and linear relationship between the corrected SI (after non-uniformity correction) and the concentration of the two coated nanoparticles were calculated in T1-weighted images. </p><p> <strong> Results </strong>: The maximum non-linear relationship between the corrected SI and the concentration of the PEG, and carboxydextran-coated nanoparticles were obtained at concentrations of 400 and 200 µmol Fe/L at a TI of 900 ms, respectively. In addition, the maximum linear relationship between the corrected SI and the concentration of the PEG, and carboxydextran-coated nanoparticles (R2=0.99) appeared at 228.184 and 205.654 µmolFe/L with a TI of 300 ms, respectively. </p><p> <strong> Conclusion </strong>: The maximum non-linear corrected SI of the carboxydextran-coated nanoparticles was slightly higher than that of the PEG-coated nanoparticles at similar TIs. However, the PEG-coated nanoparticles were better than the carboxydextran-coated nanoparticles as a T1 contrast agent for perfusion measurements. </p>
MRI, T1-weighted image, Iron oxide nanoparticles, Coating, Inversion recovery.
419
427
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-830&slc_lang=en&sid=1
Nahideh
Gharehaghaji
gharehaghaji@gmail.com; gharehaghagi@yahoo.com
200319475328460016426
200319475328460016426
Yes
Department of Radiology, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Mahmood
Nazarpoor
mnazarpoor@yahoo.co.uk; nazarpoorm@tbzmed.ac.ir
200319475328460016427
200319475328460016427
No
Department of Radiology, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran, and Faculty of Paramedicine, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
Hodaiseh
Saharkhiz
200319475328460016428
200319475328460016428
No
Department of Medical Physics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.