Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1393
10
1
gregorian
2015
1
1
29
1
online
1
fulltext
en
The effects of symbiotic therapy on anthropometric measures, body composition and blood pressure in patient with metabolic syndrome: a triple blind RCT
Endocrinology
Endocrinology
Original Research
Original Research
<p> <strong> Background: </strong>Increase in prevalence of obesity and type 2 diabetes which are of the main risk factors of metabolic syndrome, is not only the result of changes in genetic, diet or physical activity, but also an imbalance of micro flora may play an important role. Therefore, alteration of micro flora using pre/probiotic is considered as a new strategy for treatment of metabolic disorders. </p><p> <strong> Methods </strong>: The current study is a triple blind randomized controlled trial. 46 patients from both sexes, who fulfilled inclusion criteria, randomly categorized into intervention or placebo group. The intervention and placebo groups consumed 2 probiotic capsules or 2 placebo capsules during 3 months, respectively. Both groups received a weight loss diet, according to their adjusted ideal body weight. Anthropometric, body composition, blood pressure and nutritional measurements were done in the beginning, at 6th week, and at the end of the study. T-test and paired-t test were used for statistical analysis. </p><p> <strong> Results </strong>: 40 patients completed the study. BMI, WC, HC, fat mass, lean mass and blood pressure were reduced in all participants (p<0.05). Systolic blood pressure in symbiotic group was less than placebo group, significantly (p<0.05). The trend of weight loss in symbiotic group continued at least for 12 weeks while it was stopped at week 6 in placebo group. </p><p> <strong> Conclusion </strong>: Symbiotic supplement with the weight loss diet had synergistic effects on improvement in systolic blood pressure and anthropometric measurements. Based on our findings, symbiotic can postpone plateau phase of weight loss and it may prevent resistance to further weight loss. </p><p> </p>
Metabolic syndrome, Gut micro flora, Symbiotic, Body composition.
433
440
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-837&slc_lang=en&sid=1
Samira
Rabiei
samirarabiei@yahoo.com
200319475328460016586
200319475328460016586
No
Department of Clinical Nutrition & Dietetics, ShahidBeheshti University of Medical Sciences, Tehran, Iran.
Rahebeh
Shaker Hosseini
rshakerhosseini@yahoo.com
200319475328460016587
200319475328460016587
Yes
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Navid
Saadat
nsaadat@gmail.com
200319475328460016588
200319475328460016588
No
Research Institute for Endocrine Sciences, ShahidBeheshti University of Medical Sciences, Tehran, Iran.