Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1386
5
1
gregorian
2007
8
1
21
2
online
1
fulltext
en
The effect of oral clonidine pretreatment on intraocular pressure and hemodynamic stability after succinylcholine injection and intubation in cataract surgery
Anesthesia
Anesthesia
Original Research
Original Research
<p> <strong>Abstract</strong></p><p> <strong>Background:</strong> Providing better surgical conditions with meticulous control of Intraocular Pressure (IOP) is one of the most important factors that affect the success rate in ophthalmic surgery. Clonidine is a selective central α2 agonist with analgesic, antianxiety and sedative effects which makes it a good choice in premedication recently. In this study, we compared the effects of oral clonidine with oral diazepam as premedicants on IOP and hemodynamic stability after injection of succinylcholine and intubation in cataract surgery.</p><p> <strong>Methods:</strong> 109 patients with physical status 1-2 were randomly assigned in 2 groups. The C Group (54 cases) was treated with oral clonidine (3 mic/kg) and the D group (55 cases) was treated with oral diazepam (0.15 mg/kg), 2 hours before induction of anesthesia. Induction of general anesthesia in all patients was performed with sodium thiopental (5mg/kg), fontanel (2mic/kg) & succinylcholine (1.5mg/kg). Heart rate and mean arterial blood pressure were measured before and immediately after induction and 5 & 10 minutes after intravenous injection of succinylcholine. Measurements of IOP were performed before and 5 and10 minutes after injection of succinylcholine.</p><p> <strong>Results:</strong> IOPs’ were always lower in C group as compared with D group but the IOP difference between groups was only significant at 5 minutes after succinylcholine injection. Mean arterial blood pressure and pulse rate were lower in C group compared with D group and the most significant difference observed was at the time 5 minutes after succinylcholine injection.</p><p> <strong>Conclusion:</strong> Small doses of oral clonidine as premedicant can effectively reduce the IOP and provide better hemodynamic stability after intravenous injection of succinylcholine and intubation in cataract surgery.</p>
clonidine, diazepam, succinylcholine, IOP, cataract
111
114
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-171&slc_lang=en&sid=1
Hamid
Zahedi
hamid_zahedi@yahoo.com
20031947532846002143
20031947532846002143
Yes
Farabi Eye Hospital, Tehran University of Medical Sciences
M.
Nikooseresht
nikoo_mahshid@yahoo.com
20031947532846002144
20031947532846002144
No
Hamadan University of Medical Sciences. Hamadan, Iran
M.
Rahro-Taban
20031947532846002145
20031947532846002145
No