en Medical Education Medical Education Original Research Original Research <p> <strong> Background: </strong>Pamphlet is a tool used for distance continuous professional development programs. In this study, we assessed the impact of an educational pamphlet on improving prescription writing errors in general physicians’ performance. </p><p> <strong> Methods </strong>: In this randomized controlled interventional study, we prepared a training pamphlet according to the most prevalent prescription writing problems. We randomized 200 participants among general physicians affiliated with Tehran Social Security Insurance Organization, and randomly divided them into intervention and control groups. Participants’ prescriptions (N=34888) were investigated over a month, and then the prepared pamphlet was sent out to the participants in the intervention group. After three months we examined their one-month prescriptions again (N=30296) and investigated the changes in prescription errors. </p><p> <strong> Results </strong>: There was no significant difference in the mean number of prescriptions in two groups before and after intervention (p=0.076). Mean number of medicinal items reduced significantly in intervention group. Also mean number of prescriptions including injection drugs (p=0.024), Corticosteroids (p=0.036), Cephalosporin (p=0.017) and non-steroidal anti-inflammatory drugs (p=0.005) reduced significantly. No significant differences were found for other errors. </p><p> <strong> Conclusion </strong>: This study showed that use of an appropriate pamphlet has a considerable impact on improving general physicians’ performance and could be applied for continuous professional development. </p> Educational media, Pamphlet, Continuous medical education, General practitioners. 738 743 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-877&slc_lang=en&sid=1 Aeen Mohammadi aeen_mohammadi@tums.ac.ir 200319475328460018317 200319475328460018317 No Department of Medical Education, Iran University of Medical Sciences, Tehran, Iran. Rita Mojtahedzadeh r_mojtahedzadeh@tums.ac.ir 200319475328460018318 200319475328460018318 No Department of e-learning in Medical Education, Virtual School, Center for Excellence in E-learning in Medical Education, Tehran University of Medical Sciences, Tehran, Iran. Amir Hossein Emami emamiami@yahoo.com 200319475328460018319 200319475328460018319 Yes Department of Internal Medicine, Medical School, Educational Development Center, Tehran University of Medical Sciences, Tehran, Iran. Marjaneh Dehpour marjanehdehpour@yahoo.com 200319475328460018320 200319475328460018320 No Department of Medical Education, Medical School, Tehran University of Medical Sciences, Tehran, Iran.