en Gastroenterology Gastroenterology Original Research Original Research <p dir="ltr" style="text-align: justify"><strong>Background: </strong>Manometry is the gold-standard diagnostic test for motility disorders in the esophagus. The development of high-resolution manometry catheters and software displays of manometry recordings in color-coded pressure plots have changed the diagnostic assessment of esophageal disease. The diagnostic value of particular esophageal clinical symptoms among patients suspected of esophageal motor disorders (EMDs) is still unknown. The aim of this study was to explore the sensitivity, specificity, and predictive accuracy of presenting esophageal symptoms between abnormal and normal esophageal manometry findings.</p> <p dir="ltr" style="text-align: justify"><strong>Methods</strong>: We conducted a cross-sectional study of 623 patients aged 11-80 years. Data were collected from clinical examinations as well as patient questionnaires. The sensitivity, specificity, and accuracy were calculated after high-resolution manometry plots were reviewed according to the most recent Chicago Criteria.</p> <p dir="ltr" style="text-align: justify"><strong>Results</strong>: The clinical symptoms were not sensitive enough to discriminate between EMDs. Nevertheless, dysphagia, noncardiac chest pain, hoarseness, vomiting, and weight loss had high specificity and high accuracy to distinguish EMDs from normal findings. Regurgitation and heartburn did not have good accuracy for the diagnosis of EMDs.</p> <p dir="ltr" style="text-align: justify"><strong>Conclusion</strong>: Clinical symptoms are not reliable enough to discriminate between EMDs. Clinical symptoms can, however, discriminate between normal findings and EMDs, especially achalasia.</p> <p dir="ltr" style="text-align: justify"> </p> Esophageal motility disorders, Gastroesophageal reflux, Achalasia. 992 1000 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-896&slc_lang=en&sid=1 Hashem Fakhre Yaseri hfyaseri@yahoo.com 200319475328460018855 200319475328460018855 Yes Internist , Gastroenterologist, Research Center for Gastroenterology and Liver Disease, Department of Internal Medicine and Gastroenterology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. Ali Mohammad Fakhre Yaseri fyasseri@mihanmail.ir 200319475328460018856 200319475328460018856 No School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Ali Baradaran Moghaddam ak.baradaran@gmail.com 200319475328460018857 200319475328460018857 No Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Seyed Kamran Soltani Arabshhi soltarab34@gmail.com 200319475328460018858 200319475328460018858 No Internist, Department of Internal Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.