en Psychology Psychology Original Research Original Research <p dir="ltr"><strong>Background: </strong>Schizophrenia is a disorder with psychotic symptoms that severely affects personal performance. Assessing problem- focused strategies and quality of life (QoL) in patients with schizophrenia may help the clinicians to use appropriate interventions. This study was conducted to find the relationship between problem-focused coping strategies and quality of life in schizophrenic patients who referred to the clinic of Iran University of Medical Sciences in 2013.</p> <p dir="ltr"><strong>Methods</strong>: Non-random sampling was used in two stages (quota and convenience sampling). Data were collected through Demographic Questionnaire, 5-point Likert-type scale World Health Organization Quality of Life and Problem-Focused Strategies Standard Questionnaire. Four dimensions of QoL which were assessed among schizophrenic patients were as follows:  Physical health, mental health, social relationships and environmental factors. Pearson correlation coefficient and regression were used for data analysis.</p> <p dir="ltr"><strong>Results</strong>: The highest mean score (Mean= 2.7) belonged to environmental factors and the lowest score to social relationships (Mean= 2.55). Overall, there was a significant direct relationship between the QoL and problem-focused coping strategies (p= 0.024, r= 0.319).</p> <p dir="ltr"><strong>Conclusion</strong>: The Schizophrenic patients who used more problem- focused coping strategies had better QoL. Therefore, it is important to take into account problem- focus coping strategies when treating the patients. The application of this research will be crucial to clinicians and healthcare executives.</p> <p></p> Problem-Focused Strategies, Quality of Life, Schizophrenia. 1109 1115 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-917&slc_lang=en&sid=1 Shandiz Moslehi shandizmoslehi@yahoo.com 200319475328460019408 200319475328460019408 No Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran. Pezhman Atefimanesh pezhman.ata54@gmail.com 200319475328460019409 200319475328460019409 Yes International Islamic Azad University of Kish and Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran. Aliasghar Asgharnejad Farid asggharnejad.ali@gmail.com 200319475328460019410 200319475328460019410 No Department of Clinical Psychology, Iran University of Medical Sciences, Tehran, Iran.