en Gastroenterology and Liver Disease Gastroenterology and Liver Disease Original Research Original Research <p dir="ltr" style="text-align: justify;"><strong>Background: </strong>Hepatic steatosis is commonly observed in patients with chronic hepatitis C (CHC). Many studies indicate a relationship between steatosis and fibrosis progression. The aim of this study was to analyze the prevalence of hepatic steatosis and related factors in Iranian CHC patients.</p> <p dir="ltr" style="text-align: justify;"><strong>&nbsp; Methods</strong>: One hundred and fifteen consecutive patients with CHC were enrolled which were treatment-na&iuml;ve. The patients were divided into groups with and without steatosis according to the result of liver biopsy (58.3% and 41.7%, respectively). Demographic, histological, biochemical and virological factors were examined and compared in all patients.</p> <p dir="ltr" style="text-align: justify;"><strong>&nbsp; Results</strong>: In terms of host factors, body mass index (BMI), triglyceride, fasting blood glucose (FBG), necroinflammatory activity and severity in fibrosis of CHC patients with steatosis was significantly higher than the patients without steatosis. Of viral factors, HCV viral load was not significantly altered in patients with steatosis. Moreover, HCV genotypes did not meet such association. Using multivariate regression analysis, parameters of BMI values, FBG level and stage of fibrosis were independently associated with steatosis.</p> <p dir="ltr" style="text-align: justify;"><strong>&nbsp; Conclusion</strong>: Our data indicate that CHC patients are more susceptible to development of hepatic steatosis. Based on our results, grade of steatosis appears to be associated with hepatic fibrosis progression rate in CHC patients.</p> Chronic hepatitis C, Steatosis, Fibrosis, Necroinflammatory activity. 85 92 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-956&slc_lang=en&sid=1 Vahdat Poortahmasebi poortahmasebi@razi.tums.ac.ir 200319475328460021047 200319475328460021047 No Hepatitis B Molecular Laboratory, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Teh-ran, Iran. Mohammad Sajad Emami Aleagha sajad.emami@modares.ac.ir 200319475328460021048 200319475328460021048 No Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Mehdi Amiri Mamiri@uwo.ca 200319475328460021049 200319475328460021049 No Department of Cell Biology and Anatomy, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. Mostafa Qorbani mqorbani1379@gmail.com 200319475328460021050 200319475328460021050 No Department of Community Medicine, Alborz University of Medical Sciences, Karaj, Iran & Non-Communicable Disease Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Farahmand m_farahmand@razi.tums.ac.ir 200319475328460021051 200319475328460021051 No Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Hamid Asayesh asayeshpsy@gmail.com 200319475328460021052 200319475328460021052 No Department of Medical Emergencies, Qom University of Medical Sciences, Qom, Iran. Seyed Moayed Alavian alavian@thc.ir 200319475328460021053 200319475328460021053 Yes Middle East Liver Diseases (MELD) Center, Tehran, Iran.