en Public Administration & Health management and economics Public Administration & Health management and economics Original Research Original Research <p>&nbsp;&nbsp;<strong>&nbsp; Background: </strong>Economic evaluation of subcutaneous immunoglobulin therapy (SCIG) is important, and it has recently been used for treatment of patients with primary immunodeficiency (PID) diseases, and can improve allocation of resources in health care systems. The present research aimed at providing an economic assessment of SCIG and IVIG (intravenous immunoglobulin therapy) administration in Iran.<br> <strong>&nbsp;&nbsp; Methods: </strong>Data related to clinical effectiveness were obtained from a meta-analysis. Economic analysis was performed taking into account the perspective of health care providers. Incremental cost-effectiveness ratio (ICER) was applied for economic evaluation of the 2 methods, and GDP per capita was considered as a threshold.<br> <strong>&nbsp;&nbsp; Results:</strong> The results of meta-analysis suggested a higher effectiveness of SCIG compared to IVIG in serum immunoglobulin (Ig) levels (SMD= 0.336) and adverse effects (OR= 0.497), while the cost of IVIG was higher than SCIG ($1370 vs. $121). The ICER obtained in this paper ($2939 for adverse effects and $4348 for serum Ig level) was less than the GDP per capita in Iran ($4,916.10), and thus SCIG is a more cost-effective therapy for PID patients.<br> <strong>&nbsp;&nbsp; Conclusion:</strong> Switching from IVIG to SCIG is cost-effective for PID patients and is approved by the health care providers&rsquo; points of view in this study.<br> &nbsp;</p> Subcutaneous immunoglobulin, Intravenous immunoglobulin, Primary immunodeficiency, Cost-effectiveness 548 554 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-2683-1&slc_lang=en&sid=1 Hosein Shabaninejad hosein1386@gmail.com 200319475328460034190 200319475328460034190 No Department of Health Management, School of Health Management & Information Sciences, Iran University of Medical Sciences, Tehran, Iran. Asra Asgharzadeh as.asgharzadeh@gmail.com 200319475328460034191 200319475328460034191 Yes School of Health Management & Information Sciences, Iran University of Medical Sciences, Tehran, Iran, & Health Technology Assessment Group (HTAG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Aziz Rezapour rezapoor_a57@yahoo.com 200319475328460034192 200319475328460034192 No Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran. Nima Rezaei rezaei_nima@tums.ac.ir 200319475328460034193 200319475328460034193 No Research Center for Immunodeficiencies Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran, & Department of Immunology and Biology, School of Medicine Tehran University of Medical Sciences, Tehran, Iran, & Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN), Tehran, Iran.