Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1394
10
1
gregorian
2016
1
1
30
1
online
1
fulltext
en
Outcomes of assisted reproduction treatment after dopamine agonist -cabergoline- for prevention of ovarian hyper stimulation syndrome
Gynecology & Obstetrics
Gynecology & Obstetrics
Original Research
Original Research
<p dir="ltr" style="text-align: justify;"><strong>Background: </strong>Release of vascular endothelial growth factor (VEGF) by ovaries in response to HCG administration is one of the main mechanisms of ovarian hyper stimulation syndrome. Since Dopamine/dopamine receptor2 (Dp-r2) pathway activity -mediated by VEGF/ Vascular endothelial growth factor receptor 2 (VEGFR-2) signaling-, is associated with angiogenic events, dopamine agonists were used for the management of severe forms of OHSS. In order to assess the effects of Cabergoline on angiogenesis in the human endometrium, and subsequently its impacts on the implantation rate this study was conducted.</p>
<p dir="ltr" style="text-align: justify;"><strong> Methods</strong>: This historical cohort study was conducted based on existing data of 115 patients (20-40 years) whom underwent assisted reproductive treatment (ART) and with a high probability for developing OHSS between March 2007 and September 2008. Forty five cases received Cabergoline were compared to 70 control subjects. The statistical methods used were: Unpaired t-test for continuous variables and the chi-square test (or Fisher’s exact test if required) for categorical variables.</p>
<p dir="ltr" style="text-align: justify;"><strong> Results</strong>: None of the patients (treatment or control group) developed OHSS. The etiologies of infertility and administration of GnRH agonist or antagonist protocols were similar in two groups (p>0.2). Number of transferred embryos and zygote intra-fallopian transfer (ZIFT) did not differ between the two groups (p≥0.06). Implantation rate in treatment (3.1%) and control (6.6%) subjects was similar (p=0.4). No significant difference was observed in fertilization rate, chemical, clinical and ongoing pregnancies between the two groups (p>0.5).</p>
<p dir="ltr" style="text-align: justify;"><strong> Conclusion</strong>: Cabergoline can be safely administered in ART protocols to prevent OHSS, without compromising ART outcomes.</p>
Cabergoline, Ovarian Hyper stimulation Syndrome, Dopamine agonist, OHSS, Implantation rate.
504
508
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-1003&slc_lang=en&sid=1
Shohreh
Movahedi
ivfshariati69@gmail.com
200319475328460023881
200319475328460023881
No
Fellowship in infertility, Department of Infertility of Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran.
Leili
Safdarian
ivfshariati69@gmail.com
200319475328460023882
200319475328460023882
No
Fellowship in Infertility, Department of Infertility, Tehran University of Medical Sciences, Tehran, Iran.
Marzieh
Agahoseini
aghahoseini@sina.tums.ac.ir
200319475328460023883
200319475328460023883
No
Department of Infertility of Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran.
Ashraf
Aleyasin
ivfshariati69@gmail.com
200319475328460023884
200319475328460023884
No
Department of Infertility of Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran.
Sepideh
Khodaverdi
sepidehkhodaverdi@yahoo.com
200319475328460023885
200319475328460023885
Yes
Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.
Sara
Asadollah
. sara_asadolla@yahoo.com
200319475328460023886
200319475328460023886
No
Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.
Ali
Kord Valeshabad
ali_kord2006@yahoo.com
200319475328460023887
200319475328460023887
No
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Parvin
Fallahi
parvin.fallahi@yahoo.com
200319475328460023888
200319475328460023888
No
Department of Infertility of Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran.
Zahra
Rezaeeian
zahra.rezaeian2000@gmaile.com
200319475328460023889
200319475328460023889
No
Department of Infertility of Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran.