Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1394
10
1
gregorian
2016
1
1
30
1
online
1
fulltext
en
Probiotics Lactobacillus plantarum and Bifidobacterium B94: cognitive function in demyelinated model
Anatomical Sciences
Anatomical Sciences
Original Research
Original Research
<p dir="ltr" style="text-align: justify;"><strong> Background: </strong>Multiple Sclerosis (MS) is a disease of the immune system that creates damage of Learning and memory in that. Using probiotic supplements is recommended for preventing MS disease and improving memory. This study aimed to investigate the effect of Lactobacillus Plantarum (LP) and bifidobacterium B94 (BB94), on acquisition phase of spatial memory in the local demyelination of rats` hippocampus.</p>
<p dir="ltr" style="text-align: justify;"><strong> Methods</strong>: In this study, 32 male Wistar rats were divided into control, damage group and treatment groups. Treatment groups were including (LP) and (BB94). After the induction of demyelination by 3 μl of EB into the right dentate gyrus of the hippocampus in treatment groups, 1.5×10<sup>8</sup> probiotic bacteria were administered by gavage for 28 days. Data was analyzed using one-way ANOVA and Tukey post-hoc tests (p≤0.05).</p>
<p dir="ltr" style="text-align: justify;"><strong> Results: </strong>Findings demonstrated that injection of EB caused a significant increase in traveled distance (p<0.01) and also escape latency (p<0.05) compared with control group. Also, effect administrations of (LP) and (BB94) on traveled distance and escape latency were reviewed, and it was determined that administration of them do not cause significant reduction in the traveled distance compared with the lesion group. Also mentioned probiotics has no significant effect on swimming speed compared with lesion and saline groups. </p>
<p dir="ltr" style="text-align: justify;"><strong> Conclusion:</strong> According to some studies, probiotics have a positive impact on improving the performance of spatial memory and learning, although the results of the current study could not indicate finality of this assumption<span dir="RTL">. </span> It seems that more researches is needed on this subject.</p>
probiotic, demyelination, spatial memory, hippocampus.
647
653
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-1021&slc_lang=en&sid=1
Mahdi
Goudarzvand
m118medical@yahoo.com
200319475328460023111
200319475328460023111
No
Department of Pharmacology-Physiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Samira
Rasouli koohi
samirarasouli@yahoo.com
200319475328460023112
200319475328460023112
No
Antimicrobial Resistance Research Centre, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Zohreh
Khodaii
zkhodaii@yahoo.com
200319475328460023113
200319475328460023113
No
Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Somayeh
Soleymanzadeh Moghadam
so.soleymanzadeh@yahoo.com
200319475328460023114
200319475328460023114
Yes
Antimicrobial Resistance Research Centre, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.