Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1385
11
1
gregorian
2007
2
1
20
4
online
1
fulltext
en
Transpupilary thermotherapy of occult subfoveal choroidal neovascularization secondary to age related macular degeneration
Ophthalmology
Ophthalmology
Original Research
Original Research
<p> <strong>Abstract</strong></p><p> <strong>Background:</strong> Transpupillary thermotherapy is a new treatment for subfoveal choroidal neovascularization which needs further evaluation. This study was aimed to evaluate the efficacy of transpupillary thermotherapy on regression of occult subfoveal choroidal neovascularization with or without pigment epithelial detachment in patients with age-related macular degeneration.</p><p> <strong>Methods:</strong> In a case series study, patients with age-related macular degeneration who had occult subfoveal choroidal neovascularization less than 4 disc diameters with or without pigment epithelial detachment underwent transpupillary thermotherapy by diode laser. The patients were followed for 1-12 months. Main outcome measures were visual acuity changes, flattening of pigment epithelial detachment observed clinically, or absence of leakage in angiography. The data were analyzed using T-test and chi- square.</p><p> Results: The study included 30 eyes of 30 patients. Mean age of the patients was 67±7 years. Mean follow up time was 5.3±0.5 months. Visual acuity improved in 63%, remained unchanged in 20%, and worsened in 17%. Mean visual acuity improved from 1.25±0.4 log MAR (20/320) to 1.06±0.36 log MAR (20/200), (p<0.04). Choroidal atrophy or flat scar was achieved in 73% and failure to treatment was seen in 27%, (p =0.0001). Pigment epithelial detachment flattened in all cases after transpupillary thermotherapy.</p><p> <strong>Conclusion:</strong> Transpupillary thermotherapy may be a particularly useful modality for treating occult subfoveal choroidal neovascularization associated with serous pigment epithelial detachment in selected cases of age-related macular degeneration.</p>
Age-related macular degeneration, Choroidal neovascularization, Diode laser, Pigment epithelial detachment, Transpupillary thermotherapy
175
180
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-232&slc_lang=en&sid=1
M. H.
Dehghan
20031947532846002406
20031947532846002406
No
Department of Ophthalmology and Ophthalmic Research Center.
M.
Soheilian
masoud_soheilian@yahoo.com
20031947532846002407
20031947532846002407
Yes
Department of Ophthalmology and Ophthalmic Research Center, Labbafinejad Medical Center, Boostan 9,St., Pasdaran Ave., Tehran, I.R. Iran.
J.
Naghibozakerin
20031947532846002408
20031947532846002408
No
Department of Ophthalmology and Ophthalmic Research Center
A.
Papi
20031947532846002409
20031947532846002409
No
Negah Eye Center, Tehran, I.R. Iran.