en Gastroenterology and Liver Disease Gastroenterology and Liver Disease Original Research Original Research <p><strong>Background: </strong>Metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) is a common public health problem. Visfatin is secreted by visceral adipose tissue and is an adipocytokine.</p> <p>It could be a pro-inflammatory adipocytokine and is related to the metabolic syndrome and non-alcoholic fatty liver disease. This study&nbsp;evaluated the association between visfatin levels in patients with the metabolic syndrome with and without non-alcoholic fatty liver disease (NAFLD).</p> <p><strong>&nbsp;&nbsp; Methods:</strong>&nbsp;In this cross-sectional study, 120 patients with metabolic syndrome were selected. They were categorized into two groups, patients with fatty liver (n=70) and without fatty liver disease (n=50).&nbsp;Laboratory and anthropometric options such as age, sex, systolic blood pressure, fasting blood&nbsp;sugar,&nbsp;lipid profile, liver enzymes, uric acid, visfatin, insulin, BMI, waist circumference, and&nbsp;TNF-&alpha;&nbsp;were measured.&nbsp;The chi-square test, Mann-Whitney, t test, Spearman and Pearson correlations were used for the data analysis.</p> <p><strong>&nbsp;&nbsp; Results:</strong>&nbsp;There was a significant difference between the fatty liver and non-fatty liver disease with visfatin,&nbsp;BMI, FBS and&nbsp;lipid profile (p<0.05).&nbsp;The mean&plusmn;SD level of visfatin was 37.1&plusmn;1.7 ng/dl in the non-fatty liver and was 44.4&plusmn;1.5 ng/dl in fatty liver participants (p=0.02). 59% of patients with metabolic syndrome had fatty liver in ultrasonography.</p> <p><strong>&nbsp;&nbsp; Conclusion: </strong>According to this study, there was a correlation between visfatin levels and fatty liver disease.</p> Metabolic Syndrome, Visfatin, Non-alcoholic fatty liver disease 167 170 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-2984-1&slc_lang=en&sid=1 Zohreh Mousavi 200319475328460033895 200319475328460033895 No Endocrine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Azita Ganji ganjia@mums.ac.ir 200319475328460033896 200319475328460033896 Yes Gastroenterology and Hepatology Research Center. Mashhad University of Medical Sciences & Department of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Donya Farrokh Tehrani 200319475328460033897 200319475328460033897 No Radiology Department, Mashhad University of Medical Sciences, Mashhad, Iran. Ali Bahari 200319475328460033898 200319475328460033898 No Gastroenterology and Hepatology Research Center. Mashhad University of Medical Sciences & Department of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Abbas EsmaeilZadeh 200319475328460033899 200319475328460033899 No Gastroenterology and Hepatology Research Center. Mashhad University of Medical Sciences & Department of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mehdi Delghandi 200319475328460033900 200319475328460033900 No Gastroenterology and Hepatology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.