en Meta-analysis Meta-analysis Systematic Review <p><strong>Background: </strong>Different studies have investigated the association between p53 codon 72 Arg>Pro polymorphism and cancer risk. Because of the lack of consensus of the results in individual studies, we conducted this meta-analysis by pooling all currently available case&ndash;control studies to estimate the effect of p53 codon 72 Arg/Pro polymorphism on cancer susceptibility in Iranian population.<br> <strong>&nbsp;&nbsp; Methods:</strong> A comprehensive search was undertaken and primary data from all peer-reviewed journals indexed in PubMed, Google Scholar, Scopus, Magiran, Scientific Information Databank (SID), Iran Medex, and CAB abstract electronic were used to conduct this meta-analysis. We considered some exclusion and inclusion criteria to select the articles. Statistical heterogeneity was explored using the I-square. Publication bias was assessed graphically and statistically by Begg&rsquo;s funnel plot and Egger test. All statistical analyses were performed using StatsDirect software and a two- tailed test. P-value less than 0.05 was considered statistically significant for any test.<br> <strong>&nbsp;&nbsp; Results:</strong> Our dataset, which included 35 case-control studies, consisted of 2426 cancer cases and 2928 controls. Pooled OR and 95%CI indicated that codon 72 Arg>Pro polymorphism was not associated with odds of developing cancer among Iranian population in the dominant model (Pro/Pro+Arg/Pro vs. Arg/Arg:&nbsp; OR= 0.96, 95%CI= 0.74 to 1.24 chi2= 0.06, p= 0.8). Moreover, no significant association was detected in variant allele (Pro vs Arg: OR= 1.075, 95%CI= 0.91 to 1.25), homozygous (Pro/Pro vs Arg/Arg: OR=0.911 95%CI= 0.66 to 1.25), and heterozygous (Arg/Pro vs Arg/Arg: OR= 0.84, 95%CI= 0.7 to 1).<br> <strong>&nbsp;&nbsp; Conclusion:</strong> Our study revealed that p53 codon 72 Arg>Pro polymorphism was not associated with overall cancer odds in Iranian population.<br> &nbsp;</p> Meta-analysis, Cancer, p53, Iran 896 902 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-3066-1&slc_lang=en&sid=1 Daem Roshani d.roshani@muk.ac.ir 200319475328460035710 200319475328460035710 Yes Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran. Alina Abdolahi alina.abdolahi@yahoo.com 200319475328460035711 200319475328460035711 No Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran. Shima Rahmati rahmati_may66@yahoo.com 200319475328460035712 200319475328460035712 No Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.