fa Occupational Therapy Occupational Therapy Original Research Original Research <p style="text-align: justify;"><strong>Background: </strong>Despite the negative effect of fear of falling during functioning and social participation of patients with Parkinson&#39; disease, so far, only few studies have investigated its effect on the quality of life in these patients. We aimed to investigate the association between fear of falling and quality of life controlling for balance impairments based on hip and ankle strategy in drug On- and Off-phase of patients with idiopathic Parkinson&#39; disease.</p> <p style="text-align: justify;"><strong>&nbsp; Methods:</strong> In this non-experimental cross-sectional study, 139 patients with idiopathic Parkinson&#39; disease (100 male, 39 female) by mean&plusmn; SD age of 60.2&plusmn;12.27 years, mean&plusmn;SD time since diagnosis of 6.7&plusmn;5.53 years and mean&plusmn;SD Hoehn and Yahr stage of 2.8&plusmn;1.49 were selected by a simple non-probability method. Balance function was measured by a functional reach test with hip and ankle strategy. The Persian version of the self-completed Fall Efficacy Scale-International and Parkinson&#39;s disease quality of life questionnaire was used to evaluate fear of falling and quality of life, respectively.</p> <p style="text-align: justify;"><strong>&nbsp; Results:</strong> The results showed that the score of all dimensions of quality of life (i.e., mobility, activities of daily living, emotional wellbeing, stigma, social support, cognition, communication and bodily discomfort) were significantly affected by the intensity of fear of falling. Multiple regression analysis indicated a significant association between fear of falling and quality of life in a way that fear of falling explained 11% to 47% and 12% to 43% of variance in drug On-phase, as well as 8% to 45% and 9% to 48% of variance in the drug Off-phase in dimensions of quality of life after controlling for balance function based on hip and ankle strategy, respectively. In the drug On-phase, the strongest association (R=0.85, p<0.001) was found between fear of falling and mobility dimension of quality of life. In the drug Off-phase, the strongest relation was observed between fear of falling and mobility (R=0.82, p<0.001) as well as activities of daily living (R=0.78-0.79, p<0.001) dimensions.</p> <p style="text-align: justify;"><strong>&nbsp; Conclusion:</strong> This study found that fear of falling affects the quality of life of patients with Parkinson&#39; disease beyond its relationship with balance impairments based on the hip and ankle strategy in both drug On- and Off-phase.&nbsp;</p> Parkinson's disease, Quality of life, Fear of falling, Functional reach test with hip and ankle strategy. 1121 1132 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-1087&slc_lang=fa&sid=1 Maryam Mehdizadeh maryam.mehdizadeh_22@yahoo.com 200319475328460025980 200319475328460025980 No Department of Advance Technology of Medicine, Iran University of Medical Sciences, Tehran, Iran. Laleh Lajevardi laleh23275@yahoo.com 200319475328460025981 200319475328460025981 No Department of Occupational Therapy, School of Rehabilitation, Iran University of Medical Sciences, Iran University of Medical Sciences, Tehran, Iran. Seyed Amir Hassan Habibi habibi.sah@iums.ac.ir 200319475328460025982 200319475328460025982 No Movement Disorder Fellowship, Department of Neurology, Rasoul Akram Hospital, Iran University of Medical Science, Tehran, Iran. Mina Arab Baniasad baniasad@mech.sharif.edu 200319475328460025983 200319475328460025983 No Research Center for Intelligent NeuroRehabilitation Technology, Sharif University of Technology, Tehran, Iran. Delaram Baghoori d.baghoori@gmail.com 200319475328460025984 200319475328460025984 No School of Rehabilitation Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Fatemeh Daneshjoo daneshjoo.ff@gmail.com 200319475328460025985 200319475328460025985 No Neuromuscular Rehabilitation Research Center, Semnan University of Medical Science, Semnan, Iran. Ghorban Taghizadeh gh_taghizade@yahoo.com 200319475328460025986 200319475328460025986 Yes Department of Occupational Therapy, School of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran, & Rehabilitation Research Center, School of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.