Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1395
10
1
gregorian
2017
1
1
31
1
online
1
fulltext
en
Association between the circulating leptin levels and the biomarkers of oxidative stress and inflammation among Iranian overweight and obese adults
Nutrition
Nutrition
Original Research
Original Research
<p><strong>Background: </strong>Oxidative stress in obese people is an important pathogenic mechanism of an obesity-associated metabolic syndrome. We evaluated the association between circulating leptin levels with biomarkers of oxidative stress in overweight and obese participants.<br>
<strong> Methods: </strong>This study was performed on 189 overweight and obese people aged 18-60 years old. Serum leptin, superoxide dismutase (SOD), high-sensitivity C-reactive protein (hs-CRP), homocysteine (Hcy), thiobarbituric acid reactive substances (TBARS) and amyloid A (SAA) concentrations were measured. Pearson correlation and multiple linear regressions were used to assess the relationships.<br>
<strong> Results:</strong> We found that among the biomarkers of oxidative stress and inflammation in participants, serum hs-CRP and SAA were positively correlated with BMI (β=0.003, P<0.001 and β=7.83, P<0.001, respectively). This relationship remained significant even after controlling other oxidative stress and inflammatory indicators (β=0.003, p<0.001 for hs-CRP), but this association disappeared for SAA. In addition, serum hs-CRP was positively correlated with leptin (β=0.001, p=0.003). Regression analysis showed that there was no association between serum Hcy, SAA, TBARS and SOD with serum leptin concentrations<br>
<strong> Conclusion:</strong> Overall, the current study demonstrated that serum hs-CRP and SAA levels were independently correlated with BMI. Furthermore, serum hs-CRP was positively correlated with leptin. Focusing on such strategies may lead to promises for alleviating obesity and its co-morbidities.<br>
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</p>
Leptin, Obesity, Oxidative stress, Inflammation
472
477
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-3252-1&slc_lang=en&sid=1
Nahid
Aboutaleb
aboutaleb.n@iums.ac.ir
200319475328460034127
200319475328460034127
No
Physiology Research Center and Physiology Department, Faculty of Medicine Iran University of Medical Sciences, Tehran, Iran.
Mitra
Zarrati
zarrati_ms@yahoo.com
200319475328460034128
200319475328460034128
No
Faculty of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Elhameh
Cheshmazar
cheshmazar.elham@yahoo.com
200319475328460034129
200319475328460034129
No
Faculty of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Raheleh
Shokouhi Shoormasti
raheleh.shokouhi@gmail.com
200319475328460034130
200319475328460034130
No
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Elham
Razmpoosh
200319475328460034131
200319475328460034131
No
. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran & Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Farinaz
Nasirinezhad
nasirinezhad.f@iums.ac.ir
200319475328460034132
200319475328460034132
Yes
Physiology Research Center and Physiology Department, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.