en Cardiology Cardiology Original Research Original Research <p><strong>&nbsp;&nbsp;</strong><strong>&nbsp; Background: </strong>ATP2B1 and STK39 have been introduced as essential hypertension candidate genes. The association of these genes&rsquo; variations have not been studied in Iranian population yet. Here we aimed to investigate the association of ATP2B1 rs2681472 and STK39 rs35929607 polymorphisms with the risk of hypertension in an Iranian population.<br> <strong>&nbsp;&nbsp; Methods:</strong> We included 400 individuals in our case-control study: 200 cases with essential hypertension and 200 healthy sex and age matched controls. All subjects were genotyped for rs2681472 and rs35929607 using a PCR-RFLP method. Genotype and allele frequencies were compared between the two groups using chi-squared test. The association was further assessed under log-additive, dominant and recessive genetic models.<br> <strong>&nbsp;&nbsp; Results:</strong> There was no association between rs2681472 and rs35929607 polymorphisms and risk of essential hypertension in our population (p>0.05). There was also no association between the studied polymorphisms and hypertension under different genetic models. <span dir="RTL"></span><br> <strong>&nbsp;&nbsp; Conclusion:</strong> Our study indicated that rs2681472 of ATP2B1 and rs35929607 of STK39 may not have a significant effect on the risk of essential hypertension in Iranian population. More studies are still needed to validate our results.<br> &nbsp;<br> &nbsp;</p> Essential hypertension, ATP2B1, STK39, Polymorphism, Association study 78 82 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-3462-1&slc_lang=en&sid=1 Javad Jamshidi j.jamshidi@fums.ac.ir 200319475328460036740 200319475328460036740 No Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. Ali Asnaashari asnaashari7@gmail.com 200319475328460036741 200319475328460036741 No Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran. Reza Alipoor alipoor901.fums@yahoo.com 200319475328460036742 200319475328460036742 No Department of Biochemistry, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Sina Mohammadi sina.mohammadi.19958@gmail.com 200319475328460036743 200319475328460036743 No Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran. Sara Roostaei s.roustaee234@yahoo.com 200319475328460036744 200319475328460036744 No Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran. Mohammad Mahdi Samadian sa_soheidl@ymail.com 200319475328460036745 200319475328460036745 No Department of Medical Genetics, Mashhad University of Medical Sciences, Mash-had, Iran. Saiedeh Honamrmand Aliabadi s.honarmand.s12@gmail.com 200319475328460036746 200319475328460036746 No Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran. Ehsan Bahramali ebahramali@fums.ac.ir 200319475328460036747 200319475328460036747 Yes Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran & Department of Cardiology, Fasa University of Medical Sciences, Fasa, Iran.