en Health Technology Assessment Health Technology Assessment Original Research Original Research <p>&nbsp;&nbsp;<strong>&nbsp; Background: </strong>Bariatric surgery with the improvement of obesity-related diseases, increases longevity and quality of life and is more cost-effective when compared to non-surgical Procedures.</p> <p><strong>&nbsp; Objective:</strong> The aim of this study is to compare the cost-effectiveness of Laparoscopic Sleeve Gastrectomy (LSG) and Laparoscopic Roux-en-Y Gastric Bypass (LRYGB).</p> <p><strong>&nbsp; Method:</strong> This study was performed in two stages. Initially, a cross-sectional study was carried out for costing LSG and LRYGB in Rasoul Akram and Bahman hospitals in Tehran in the year 2014. Direct costs for each surgical procedure were calculated according to the average time of surgery in both the private and public sectors. In the second stage, using Outcome (&Delta;BMI) collected by means of a systematic review study and cost data; cost effectiveness of two surgical procedures was examined by ICER analysis and compared with threshold limit. The Perspective of this analysis was health system.&nbsp;</p> <p><strong>&nbsp; Results:</strong> The direct cost of services for LRYGB was $ 2991.5 (98121659 Rials) in the public sector and $4221.9 in the private sector. In LSG, it was $ 1952.9 (64055468 R) in the public sector and $ 3177.2 in the private sector. ICER for LSG was 720.48(23631855 R) and $716.27 (23493924 R) in private and public sector respectively.&nbsp;</p> <p><strong>&nbsp; Conclusion:</strong> In this study, LSG procedure when compared to LRYGB was cost effective. The ICER obtained indicated that LSG surgery in comparison to LRYGB was $716.27 (23493924 R) and $720.48(23631855 R) in the public and private sector respectively. Moreover, per unit change in BMI was less than the threshold.</p> <p></p> Cost-effectiveness, Laparoscopic sleeve gastrectomy, Laparoscopic Roux-en-Y gastric bypass, Tehran 124 129 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-1111&slc_lang=en&sid=1 Fateme Arabi Basharic 200319475328460031252 200319475328460031252 Yes Mashhad University of Medical Sciences, Mashhad, Iran. Alireza OlyaeeManesh arolyaee@gmail.com 200319475328460031253 200319475328460031253 No National Institute for Health Research, Tehran University of Medical Sciences, Tehran, Iran. Behzad Raei 200319475328460031254 200319475328460031254 No School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Reza Goudarzi 200319475328460031255 200319475328460031255 No Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. Morteza Arab Zozani 200319475328460031256 200319475328460031256 No Iranian Center of Excellence in Health Management, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran. Mohammad Ranjbar Ezzatabadi 200319475328460031257 200319475328460031257 No Health Policy Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.