Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1396
11
1
gregorian
2018
2
1
32
1
online
1
fulltext
en
Raphe nuclei echogenicity changes in obsessive-compulsive disorder
Psychiatry
Psychiatry
Original Research
Original Research
<strong>Background: </strong>Dysregulation of serotonin system is hypothesized to play the main role in the etiology of obsessive-compulsive disorder (OCD). Transcranial sonography (TCS) is a helpful noninvasive and low-cost tool for the assessment of subcortical brain architectures, mainly basal nuclei, cerebellar central structures<s>,</s> and midbrain. In this study, an ultrasound assessment was performed for a sample of the patients with OCD and healthy control group to evaluate echogenicity of midbrain raphe nuclei (RN).<br>
<strong> Methods: </strong>A total of 35 patients with OCD and 35 healthy controls of similar age and sex entered the study. Semi-structured clinical interview was performed according to the DSM IV-TR criteria to verify OCD. Echogenicity of the midbrain RN was assessed by an experienced neurologist applying TCS. The echogenicity of the 2 groups was compared using chi- square test. SPSS software (version 18, PASW) was used for statistical analysis and p-value of less than 0.05 was considered significant.<br>
<strong> Results:</strong> In this study, 15 OCD patients (42.9%) and 11 (31.4%) controls showed decreased echogenicity of midbrain RN. Also, the results of the chi-square test showed that the midbrain RN echogenicity was not significantly lower in patients with OCD compared to the control group (p= 0.322).<br>
<strong> Conclusion:</strong> Although decreased midbrain RN echogenicity is a characteristic of patients with major depression, it was not shown in OCD patients in this study, which can be explained by the involvement of RN projections rather that RN serotoninergic neurons.
Transcranial sonography, Obsessive-compulsive disorder, Raphe nuclei, Echogenicity
531
534
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-624-3&slc_lang=en&sid=1
Nahid
Mohammadzadea
nahid.mohammadzade@yahoo.com
200319475328460040870
200319475328460040870
No
Department of Neurology, Hazrat Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran
Mohammad Reza
Shalbafan
drmrsh@gmail.com
200319475328460040871
200319475328460040871
No
Mental Health Research Center, Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Vahid
Shariat
vahid.shariat@gmail.com
200319475328460040872
200319475328460040872
No
Mental Health Research Center, Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Babak
Zamani
zamba3@yahoo.com
200319475328460040873
200319475328460040873
No
Department of Neurology, Firouzgar Hospital, Iran University of Medical Sciences, Tehran, Iran
Behnam
Shariati
behnamshariatimd@gmail.com
200319475328460040874
200319475328460040874
No
Department of Psychiatry, Hazrat Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran
Fateme
Omrani
omrani.fatemeh86@gmail.com
200319475328460040875
200319475328460040875
No
Department of Neurology, Hazrat Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran
Mohammad
Rohani
mohammadroohani@gmail.com
200319475328460040876
200319475328460040876
Yes
Department of Neurology, Hazrat Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran