Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1387
5
1
gregorian
2008
8
1
22
2
online
1
fulltext
en
Correlation between urine macrophage migration inhibitory factor (MIF)/creatinine ratio and time after kidney transplantation
Urology and Nephrology
Urology and Nephrology
Original Research
Original Research
<p> <strong>Abstract </strong></p><p> <strong>Background:</strong> Despite the long-standing association of macrophage migration inhibitory </p><p> factor (MIF) with delayed-type hypersensitivity response, the potential role </p><p> of MIF in chronic allograft nephropathy is unknown. The association between upregulation of MIF expression, macrophage and T cell infiltration and the severity of </p><p> chronic allograft nephropathy suggests that MIF may be an important mediator in the </p><p> process of chronic allograft nephropathy. Therefore, the aims of this study were to </p><p> measure urine concentration of MIF after renal transplantation, and to determine if it </p><p> increases with time. </p><p> <strong>Methods:</strong> In this prospective cross-sectional study twenty-two pediatric patients </p><p> (case, group A) who received kidney transplants between 1999 and 2006, and forty </p><p> healthy children (control, group B) were recruited. Urine MIF and creatinine were </p><p> assessed in all patients. Urine MIF concentrations were quantitated by ELISA. </p><p> <strong>Results:</strong> The mean ratios of urine MIF/Creatinine (Cr) were calculated as </p><p> 5.046(SEM=2.04) pg/μmol creatinine in transplanted-kidney patients (group A) and </p><p> 1.85(SEM=0.35) pg/μmol creatinine in healthy individuals (group B). Agood significant </p><p> correlation was seen between urine MIF/Cr ratio and time after kidney transplantation </p><p> in recipients (P=0.002, rSpearman = +0.633). </p><p> <strong>Conclusion:</strong> This study shows significant correlation between urine MIF/Cr ratio </p><p> and time passed after transplantation. Increasing MIF/Cr ratios were seen in patients </p><p> with a longer post transplantation period. Therefore, it is necessary to determine the </p><p> role of macrophages in chronic renal nephropathy especially chronic rejection with </p><p> additive studies and then study the effect of anti-MIF antibodies in the treatment of </p><p> this condition.</p><p> </p>
Chronic allograft nephropathy, macrophage migration inhibitory factor (MIF), creatinine, transplantation
55
62
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-43&slc_lang=en&sid=1
Hasan
Otukesh
20031947532846001580
20031947532846001580
No
Urology and Nephrology Research Center, Labbafi Nejad Hospital, Tehran, Iran.
Seyed-Mohammad
Fereshtehnejad
sm_fereshtehnejad@yahoo.com.
20031947532846001581
20031947532846001581
Yes
Medical Student Research Committee, Iran University of Medical Sciences and Health Services, Tehran, Iran
,Rozita
Hoseini
20031947532846001582
20031947532846001582
No
Urology and Nephrology Research Center, Labbafi Nejad Hospital, Tehran, Iran.
Majid
Chalian
20031947532846001583
20031947532846001583
No
Iran University of Medical Sciences and Health Services, Tehran, Iran.
Arash
Bedayat
20031947532846001584
20031947532846001584
No
Iran University of Medical Sciences and Health Services, Tehran, Iran.
Reza
Salman Yazdi,
20031947532846001585
20031947532846001585
No
Rooyan Institiute, Tehran, Iran.
Amir Ebrahim
Safarzadeh
20031947532846001586
20031947532846001586
No
Iran University of Medical Sciences and Health Services, Tehran, Iran.
Saeed
Sabaghi
20031947532846001587
20031947532846001587
No
Rooyan Institiute, Tehran, Iran.
Saeed
Mahdavi
20031947532846001588
20031947532846001588
No
Rooyan Institiute, Tehran, Iran.