en Neurology Neurology Original Research Original Research <strong>&nbsp;&nbsp;</strong><strong>&nbsp; Background: </strong>Head trauma is one of the common reasons for patient attendance in the emergency ward. This study investigated the effect of tranexamic acid as a cheap, easily available antifibrinolytic drug on reducing the progress of cerebral hemorrhage compared to placebo.<br> &nbsp;&nbsp; <strong>Methods:</strong> This double-blind controlled clinical trial was performed on 120 traumatized patients presenting to the emergency room of Shahid Rahnemoon hospital during 2014-2015, Yazd, Iran. Those patients who met the inclusion criteria were randomly allocated into 2 groups. Group A received tranexamic acid, while group B received placebo parenterally. Finally, 56 patients in Group A and 44 in Group B were analyzed. The patients underwent brain CT scan and were followed up for ICU stay in days. Also, the number of patients who died during the first 7 days of hospitalization was recorded. The data were analyzed with SPSS20 using independent samples t test and chi-square test.<br> &nbsp;&nbsp; <strong>Results:</strong> The mean age of the patients was 41&plusmn;20.27 years. Also, 20 patients (20%) were female and 80 were male (80%). There was no significant difference between the drug group and placebo group in the rate of hemorrhage volume progress (p=0.824). Regarding patients&rsquo; ICU stay, the ICU stay of the tranexamic acid group decreased significantly compared to the placebo group (p=0.001). No significant difference was found between the intervention group and placebo group in the mortality rate of patients during the first 7 days of hospitalization (p=0.236).<br> &nbsp;&nbsp; <strong>Conclusion:</strong> Tranexamic acid has no effect on reducing cerebral hemorrhage volume in patients. Although this drug was not effective in reducing mortality rate in patients, it decreased their ICU stay. Trauma, Cerebral, Hemorrhage, Tranexamic acid, Clinical Trial 735 740 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-2852-3&slc_lang=en&sid=1 Fateme Mojallal fmodjallal@ssu.ac.ir 200319475328460064299 200319475328460064299 No Trauma Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mehrnaz Nikooieh M.nekooieh@ssu.ac.ir 200319475328460064300 200319475328460064300 No School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Majid Hajimaghsoudi hajimaghsoudi@ssu.ac.ir 200319475328460064301 200319475328460064301 No Trauma Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mehdi Baqherabadi m.bagherabadi@ssu.ac.ir 200319475328460064302 200319475328460064302 Yes School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mohammadali Jafari malijafari@ssu.ac.ir 200319475328460064303 200319475328460064303 No School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Alireza Esmaeili 200319475328460064304 200319475328460064304 No School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Naser Mohammad Karimi N.mohamadkarimi@ssu.ac.ir 200319475328460064305 200319475328460064305 No School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Ehsan Zarepur ehsanzarepur@resident.mui.ac.ir 200319475328460064306 200319475328460064306 No Cardiology resident, PhD candidate, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran