Medical Journal of the Islamic Republic Of Iran

en The role of Human papilloma virus (HPV) genotyping in recurrent respiratory papillomatosis in Rasoul Akram Hospital Otorhinolaryngology Otorhinolaryngology Original Research Original Research Background: The most common laryngeal mass in children is recurrent respiratory papillomatosis (RRP). Studies have attempted to correlate viral typing and its aggressiveness. Method: 29 patients with histologically confirmed RRP enrolled in adjuvant therapies. Patients underwent several surgical interventions. Results: HPV genotyping demonstrated 45% HPV-6 and 55% HPV-11. The mean age at the first surgical intervention was 52.39 months (SD=102.28) (range from 4 months to 426 months). The mean number of surgical intervention was 10.39 (SD=7.76) (range from 2 to 30). The mean time of surgical intervals was 4.63 months (SD=4.02) (range from 2 to 24 months). In fourteen patients (48%) tracheotomy was done. All patients who had tracheotomy received alpha-interferon. One of our cases was a male who had pulmonary extension with HPV-6. Conclusion: A review of patients with RRP was regarding to HPV genotyping and need for adjuvant therapy and tracheostomy. Mean number of surgical procedure was 10/40 and nearly fourteen patients (48%) need to tracheotomy. The clinical differences between HPV6 and HPV11 disease may not be accurately predictable. Patients with less age and with HPV-11 seemed to have more severe problems, but these differences were not statistically significant which needs much more investigations for reasonable starting point of evaluation for these differences. Respiratory tract diseases, Papillomatosis, Laryngeal neoplasms, Human papillomavirus, Human papillomavirus. 90 93 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-304&slc_lang=en&sid=1 Farzad Izadi izadimd@yahoo.com 20031947532846007492 20031947532846007492 No Department of Otolaryngology, ENT.HNS research center, Tehran University of Medical Sciences, Tehran, Iran. Rasool Hamkar rhamkar@ Sina.tums.ac.ir 20031947532846007493 20031947532846007493 No Department of Virology, Tehran University of Medical Sciences, Tehran, Iran. Hadi Ghanbari ghanbari_md@tums.ac.ir 20031947532846007494 20031947532846007494 Yes Department of Otolaryngology, ENT.HNSresearch center, Tehran University of Medical Sciences. Rasoul Akram Hospital/Niayesh St. Sattarkhan Avenue, Tehran, Iran. Fereshteh Abdolmotallebi fereshteh_abdolmotallebi@yahoo.com 20031947532846007495 20031947532846007495 No Department of Otolaryngology, ENT.HNS research center, Tehran University of Medical Sciences. Hesam Jahandideh hesam_jahandideh@yahoo.com 20031947532846007496 20031947532846007496 No Department of Otolaryngology, ENT.HNS research center, Tehran University of Medical Sciences, Tehran, Iran.