Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1396
11
1
gregorian
2018
2
1
32
1
online
1
fulltext
en
Association of circulating omentin-1 level with lung cancer in smokers
Clinical Biochemistry
Clinical Biochemistry
Original Research
Original Research
<strong> </strong><strong> Background: </strong>Omentin has recently been considered as an adipokine secreted from visceral fat and is expressed in the lungs, heart, ovary etc. Various studies have shown that omentin may have an anti-inflammatory role in the inflammatory process and the amount of omentin alters in some cancers, such as colorectal, prostate and renal cells cancers, changes. The serum level of omentin, however, remains unknown in non-patient smokers and the smokers afflicted with lung cancer. Therefore, this study examines the serum levels of omentin in smokers suffering from lung cancer.<br>
<strong> Methods:</strong> The amount of serum omentin was measured in 45 patients with lung cancer and 61 age - and sex - matched controls (30 smokers and 31 non-smokers) using enzyme-linked immunosorbent assay (ELISA) kit. Data were analyzed using SPSS-16, and one-way analysis of variance and Scheffe post hoc test were used to determine and compare the serum levels of omentin in different types of lung malignancies. Significance level was set at p≤0.05.<br>
<strong> Results:</strong> The amount of circulating omentin for healthy non-smokers and non-patient smokers was 3.55±0.57 ng/l and 5.43±1.95 ng/l, respectively (p<0.001). The serum level of omentin was 3.63±0.70 ng/l for smokers afflicted with cancer (p<0.001 compared with non-patient smokers: 5.43±1.95).<br>
<strong> Conclusion:</strong> The meaningful decrease in omentin levels in smokers with lung cancer can be considered as a risk factor in smokers and can use as a significant factor in the prognosis of lung cancer in these people.<br>
Smoker, Omentin, Lung cancer
779
783
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-4116-1&slc_lang=en&sid=1
Mohammad Hassan
Khadem Ansari
mhansari@hotmail.com
200319475328460042393
200319475328460042393
No
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Mahdia
Gholamnejad
Gholamnejad@gmail.com
200319475328460042394
200319475328460042394
No
Pulmonology Department, Urmia University of Medical Sciences, Urmia, Iran
Khadije
Meghrazi
kmeghrazi@gmail.com
200319475328460042395
200319475328460042395
Yes
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Hamid Reza
Khalkhali
Khalkhali@umsu.ac.ir
200319475328460042396
200319475328460042396
No
Department of Epidemiology and Biostatistics, faculty of medicine, Urmia University of medical sciences, Urmia, Iran