Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1397
11
1
gregorian
2019
2
1
33
1
online
1
fulltext
en
The accuracy of white blood cell count in the diagnosis of acute appendicitis using age-sex-adjusted receiver operating characteristic approach
Surgery
Surgery
Original Research
Original Research
<strong>Background: </strong>White blood cell (WBC) counts are commonly used for the diagnosis of acute appendicitis in the early stages of pain. However, the effect of certain confounders, particularly age and sex, has been less focused. The purpose of this study was to investigate the diagnostic accuracy of white blood cells in the prediction of acute appendicitis using age-sex-adjusted receiver operating characteristic (ROC) curve.<br>
<strong>Methods: </strong>In this cross sectional study, 131 patients who had undergone appendectomy were studied during 2010-2011. Patients were placed in the normal appendix and acute appendicitis groups. ROC regression was used to identify the effects of the variables of age and sex on the diagnostic accuracy of WBCs using the area under the ROC curve (AUC). Statistical analysis was conducted in Stata 12 software.<br>
<strong>Results: </strong>In ROC regression method, the AUC for the variable of WBC was 0.643 (95% CI: 0.555-0.725) without adjustment for age and sex variables, 0.672 (0.584-0.751) with an age-adjusted variable, 0.698 (0.612-0.775) with a sex-adjusted variable, and 0.710 (0.624-0.786) with both age-sex adjusted variables.<br>
<strong>Conclusion:</strong> Results indicated that age-sex adjusted variables increased the diagnostic accuracy of the WBC test for predicting acute appendicitis using ROC regression method for the WBC test.<br>
White blood cell counts, Acute appendicitis, Area under the ROC Curve, ROC regression
849
853
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-2060-2&slc_lang=en&sid=1
Mohammad
Rafiei
rafeie@yahoo.com
200319475328460062241
200319475328460062241
No
Department of Biostatistics and Epidemiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
Naser
Mohammad Gholi Mezerji
mezerji@gmail.com
200319475328460062242
200319475328460062242
No
Department of Biostatistics, Student Research Committee, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
Zahra
Shayan
shayanz@sums.ac.ir
200319475328460062243
200319475328460062243
Yes
Trauma Research Center, Rajaee (Emtiaz) Trauma Hospital, Department of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Ghasem
Mosayebi
gmosayebi@yahoo.com
200319475328460062244
200319475328460062244
No
Department of Immunology and Microbiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran