Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1396
11
1
gregorian
2018
2
1
32
1
online
1
fulltext
en
Molecular prevalence of parvovirus B19 among HIV1-infected patients in Iran
Virology
Virology
Original Research
Original Research
<strong> </strong><strong> Background: </strong>Different outcomes of parvovirus B19 (B19V) infection in immunocompromised patients, including HIV1-infected persons, may be life-threatening. Considering the hematologic disorders associated with B19V infection, this study aimed to investigate the prevalence of B19V infection among HIV1-infected individuals in Iran.<br>
<strong>Methods: </strong>Serum samples from 100 HIV1-infected patients were analyzed for B19 viral DNA using real-time PCR assay. COBAS TaqMan HIV-1 test was performed for quantitative measurements of HIV-1 RNA in the patients’ sera.<br>
<strong>Results:</strong> Real-time PCR analysis revealed that 10 out of 100 cases (10%) were positive for B19V infection. Across various age groups, the B19V infection was more prevalent among patients within the age range of 21-40 years. Higher prevalence of B19V infection was observed among HIV1-infected patients with a viral load of higher than 400 copies/mL.<br>
<strong>Conclusion: </strong>Despite limitations, this study may set the stage for further evaluations with larger sample sizes to elucidate the potential role of B19V in hematologic disorders, which may result in exacerbation of the disease in HIV1-infected patients. Moreover, as it has been shown that B19V infection can be treated using intravenous immunoglobulin (IVIG) therapy, available treatments may help improve the quality of life in HIV-infected persons.
Parvovirus B19, HIV-1, Anemia, AIDS
659
662
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-2447-5&slc_lang=en&sid=1
Seyed Jalal
Kiani
jalalkiani1@yahoo.com
200319475328460042119
200319475328460042119
No
Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Davod
Javanmard
djavanmard@hotmail.com
200319475328460042120
200319475328460042120
No
Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Hadi
Ghaffari
drhadighaffari@gmail.com
200319475328460042121
200319475328460042121
No
Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Ahmad
Tavakoli
ahmad.tavakoli66@gmail.com
200319475328460042122
200319475328460042122
No
Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Helya Sadat
Mortazavi
heliamortazavi.13@gmail.com
200319475328460042123
200319475328460042123
No
Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Farah
Bokharaei-Salim
bokharaeifarah@gmail.com
200319475328460042124
200319475328460042124
No
Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Zahra
Bangaleh
zbangaleh1@gmail.com
200319475328460042125
200319475328460042125
No
Core Laboratory, Iran University of Medical Sciences, Tehran, Iran
Seyed Hamidreza
Monavari
monavari.hr@iums.ac.ir
200319475328460042126
200319475328460042126
Yes
Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran