Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1398
11
1
gregorian
2020
2
1
34
1
online
1
fulltext
en
Assessing the quality of meta-analyses in systematic reviews in pharmaceutical research in Iran by 2016: A systematic review
Pharmacology
Pharmacology
Systematic Review
<strong> </strong><strong> Background: </strong>Meta-analyses, like all other studies, may be poorly designed and implemented. This study was designed to determine the quality of meta-analyses in systematic reviews in the field of pharmaceutical research in Iran.<br>
<strong>Methods:</strong> Web of Science Core Collection, EMBASE, Ovid Medline, CINAHL, Scopus, and PubMed were systematically searched on June 4, 2017. The search was limited to the researches in the field of pharmaceutical studies. Based on inclusion criteria, 104 systematic reviews with meta-analysis (SRMA) were selected and assessed using quality assessment tools introduced by Higgins.<br>
<strong>Results: </strong>Participants, experimental interventions, and outcomes were reported in all the articles. Comparator intervention and study design were correctly reported in 103 (99.04%) and 101 (97.12%) articles, respectively. The comprehensive search strategy was available only in 48 articles (46.16%), and there was no evidence of a comprehensive search in 56 articles (53.84%). Risk of bias was investigated in 78 articles (75%). Also, funnel plots were the most commonly used method for reporting the bias in 64 articles (46.42%).<br>
<strong>Conclusion:</strong> In many of the meta-analyses, several items of the tool that represented a high-quality meta-analysis were absent. According to the findings, the comprehensive search and quality assessment were not at an appropriate level. Thus, the importance of reproducibility of information and quality assessment of included studies should be emphasized.
Meta-analysis, Pharmaceutical research, Bias, Research design
209
216
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-4199-2&slc_lang=en&sid=1
Alireza
Amanollahi
amanollahi.a@gmail.com
200319475328460063853
200319475328460063853
No
Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Maziar
Moradi-Lakeh
moradilakeh.m@iums.ac.ir
200319475328460063854
200319475328460063854
No
Preventive Medicine and Public Health Research Center, Department of Community Medicine, Iran University of Medical Sciences, Tehran, Iran
Farhad
Shokraneh
Farhad.Shokraneh@nottingham.ac.uk
200319475328460063855
200319475328460063855
No
Cochrane Schizophrenia Group, The Institute of Mental Health, A Partnership Between the University of Nottingham and Nottinghamshire Healthcare NHS Trust, Nottingham, UK
Yousef
Bashiri
شکرانه
yousef_bashiri@yahoo.com
200319475328460063856
200319475328460063856
No
Department of Biostatistics, School of Allied Medical Sciences, Shahid Bebeshti Univercity of Medical Sciences, Tehran, Iran
Leily
Mahmudi
liley.mahmudi@gmail.com
200319475328460063857
200319475328460063857
Yes
Department of Community Medicine, Dezful University of Medical Sciences, Dezful, Iran