Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1398
11
1
gregorian
2020
2
1
34
1
online
1
fulltext
en
Evaluating the effect of Coriandrum sativum syrup on being migraine-free using mixture models
Biostatistics and Epidemiology
Biostatistics and Epidemiology
Original Research
Original Research
<strong>Background: </strong>Coriandrum sativum (coriander) is prescribed as a treatment for headache in traditional Persian medicine. Several investigations have been carried out to find the medicinal properties of this plant. However, no study has evaluated the effectiveness of this plant on becoming migraine-free.<br>
<strong> Methods: </strong>Sixty-eight migraineurs were randomly allocated to two equal groups of intervention and control. Each received 500 mg of<a name="OLE_LINK1"> sodium valproate</a> in addition to 15 mL of coriander or placebo syrup three times a day. We followed subjects and recorded their migraine duration in the 1<sup>st</sup>, 2<sup>nd</sup>, 3<sup>rd</sup>, and 4<sup>th</sup> weeks. We applied an appropriate statistical model so as to consider special features of the data, which led to more accurate results using SAS 9.4<br>
<strong> Results:</strong> Our findings showed that the probability of being migraine-free was not only considerably higher in final weeks of the study (p<0.001) in all patients of the intervention group than placebo group, but it was also significantly higher in patients less than 30 years of age compared to patients older than 30 years old. Migraine duration in migraineurs using coriander syrup reduced considerably during the study (p<0.001).<br>
<strong> Conclusion: </strong>The finding of this study revealed that coriander has a significant effect both on the probability of being migraine free and the duration of migraine attacks. Its effects were more significant during the final weeks of study.<br>
Migraine headache, Coriandrum sativum, Herbal drug, Clinical trial, Mixture model
311
317
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-4333-1&slc_lang=en&sid=1
Samaneh
Mansouri
samaneh.mansoory@gmail.com
200319475328460063943
200319475328460063943
No
Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Iraj
Kazemi
i_kazemi@yahoo.com
200319475328460063944
200319475328460063944
No
Department of Statistics, Faculty of Sciences, University of Isfahan, Isfahan, Iran
Ahmad Reza
Baghestani
baghestani@sbmu.ac.ir
200319475328460063945
200319475328460063945
Yes
Physiotherapy Research Center, Department of Biostatistics, Faculty of Para-medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Farid
Zayeri
zaerif38@gmail.com
200319475328460063946
200319475328460063946
No
Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Zahra
Ghorbanifar
ghorbaniza14@gmail.com
200319475328460063947
200319475328460063947
No
Persian Medicine Department, School of Medicine, AJA University of Medical Sciences, Tehran, Iran