en Gastroenterology Gastroenterology Systematic Review <strong>Background: </strong>Colorectal cancer counts as the third prevalent type of cancer and the fourth cause of death worldwide. The second-generation colon capsule endoscopy (CCE-2) is a new technology for the diagnosis of colon cancer. The aim of this review was to provide information on the diagnostic accuracy (diagnostic effectiveness) of the second-generation colon capsule endoscopy compared to colonoscopy for the diagnosis of colon cancer and disorders.<br> &nbsp;&nbsp; <strong>Methods:</strong> A systematic review of literature in PubMed, Scopus, Science Direct, and Cochrane Library and Iranian databases, such as MagIran, SID, Irandoc, the grey literature (via Google Scholar) was conducted on February 30, 2018. QUADAS-2 was used to assess the quality of the studies.&nbsp; MetaDiSc 2.0 software was used for the meta-analysis.<br> &nbsp;&nbsp; <strong>Results: </strong>In this review, 480 records were identified. Eight prospective cohort articles were included among which 7 included in the meta-analysis. For the diagnosis of colorectal polyps with a diameter of 6-10 mm, the pooled sensitivity and specificity were 84% (95% CI, 80% -88%) and 88% (95%CI, 85% -90%). For the diagnosis of 10 mm or bigger colorectal polyps, the pooled sensitivity and specificity were 84% (95% CI, 76%-89%) and 96% (95% CI, 94 %-97%). The sensitivity and specificity of the capsule in the detection of any size polyps were 93% (95% CI, 97%-84%) and 66% (95% CI, 48%-81%), respectively.<br> &nbsp;&nbsp; <strong>Conclusion:</strong> There is little evidence to show the accuracy of CCE-2. Nevertheless, this review showed that the second-generation colon capsule endoscopy has good accuracy in the detection of polyps and colorectal cancer among high- and middle-risk patients.<br> &nbsp; Colon capsule endoscopy, Colonic polyp, Accuracy, CCE-2, Colonoscopy 567 573 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-4473-1&slc_lang=en&sid=1 Samira Alihosseini sah8606@gmial.com 200319475328460064150 200319475328460064150 No Department of Health Services Management and Policy and Economics, School of Health Management and Information Sciences, Kerman University of Medical Sciences, Kerman, & Think-tank Office, Iran University of Medical Sciences, Tehran, Iran Aidin Aryankhesal a.aryankhesal@gmail.com 200319475328460064151 200319475328460064151 No Health Management and Economics Research Center, Department of Health Services Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran Asma Sabermahani a-saber@kmu.ac.ir 200319475328460064152 200319475328460064152 Yes Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran