en Health Management and Information Sciences Health Management and Information Sciences Systematic Review <strong>&nbsp;&nbsp;</strong><strong>&nbsp; Background: </strong>Burnout is one of the main factors in reducing the performance quality among hospital staff. Appropriate interventions can reduce burnout among physicians and nurses and result in promotion of the quality of services provided at hospitals. The present study aimed to provide a more comprehensive understanding of the interventions on burnout reduction among hospital physicians and nurses.<br> &nbsp;&nbsp; <strong>Methods:</strong> Studies were searched from January 2000 to June 2017 in PubMed, Embase, Scopus, Cochrane, and Web of Science. Randomized clinical trials (RCTs) and pretest-posttest studies that had interventions to reduce the burnout of physicians and nurses were included. However, studies conducted on medical and nursing students and nonmedical providers or beyond hospitals were excluded.<br> &nbsp;&nbsp; <strong>Results:</strong> Based on the study inclusion criteria, 12 RCTs and 6 pretest-posttest studies were included in the review. Most of the included studies were from Netherlands, the United States, and England. The interventions included team-based program, EMH-approach, and coping and communication skills training. Most of the interventions had a positive effect on burnout reduction. Nevertheless, some studies had no significant impact.<br> &nbsp; <strong>Conclusion:</strong> The results showed that the most interventions used to improve burnout were improving communication skills, teamwork, participatory programs, and psychological interventions (Yoga, meditation, and mindfulness). The impact of these interventions can increase mental health in the long term. Burnout is a complicated problem and should be treated by combining interventions.<br> &nbsp; Burnout, Mental health, Nurses, Physicians, Hospital, Systematic review 467 474 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-4499-1&slc_lang=en&sid=1 Aidin Aryankhesal a.aryankhesal@gmail.com 200319475328460062524 200319475328460062524 No Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran Roghayeh Mohammadibakhsh r.mohammadib@yahoo.com 200319475328460062525 200319475328460062525 Yes Department of Health Services Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran Yadollah Hamidi hamidi@umsha.ac.ir 200319475328460062526 200319475328460062526 No Department of Health Management and Economics, School of Public Health and Research Center for Public Health, Hamadan University of Medical Sciences, Hamadan, Iran Saeideh Alidoost alidoostsd@yahoo.com 200319475328460062527 200319475328460062527 No Department of Health Services Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran Masoud Behzadifar masoudbehzadifar@gmail.com 200319475328460062528 200319475328460062528 No Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Rahim Sohrabi sohrabi2003@gmail.com 200319475328460062529 200319475328460062529 No Iranian Social Security Organization, Zanjan Province Health Administration, Zanjan, Iran Zeynab Farhadi farhadi_zaynab@yahoo.com 200319475328460062530 200319475328460062530 No Department of Health Services Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran