Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1384
11
1
gregorian
2006
2
1
19
4
online
1
fulltext
en
BENEFICIAL EFFECT OF LOW DOSE CYCLOSPORINE WITH MMF (MYCOPHENOLATE MOFETIL) IN RENAL ALLOGRAFT RECIPIENTS
Nephrology
Nephrology
Original Research: Clinical Science
Original Research: Clinical Science
Background: Calcineurin inhibitors (CNI) have significantly reduced the incidence
of acute rejection. Nephrotoxicity however may contribute to long-term allograft
dysfunction. Mycophenolate mofetil (MMF) may allow cyclosporine (CsA) dose reduction
without increasing the risk of rejection.
Methods: In seventy-eight living unrelated kidney transplant patients with renal
dysfunction, we studied the effect of CsA dose reduction in association with MMF on
renal function and cardiovascular risk profile.
Results: We reduced the cyclosporine dose from mean 3.5±0.94 mg/kg/d to
2±0.51 mg/kg/d,p<O.OOOl. Mean follow up duration was 22.99±8.98 weeks. The
reduction of CsA was associated with decrement of median serum creatinine from
1. 7±0.99 mg/dL to 1.3±0.52 mg/dL,p<O.OOO 1. We found improvement in lipid profile,
mean cholesterol level from 212.73±41.72 to 199.69±37.33 mg/dL,p<0.002
and also with triglyceride from 195.28±92.21 to 167.64±60.82 mg/dL,p<0.005. No
rejection episodes occurred, and an improvement in systolic and diastolic pressure was
observed from 131.41±21.26 to 127.83±17.53 rnm/Hg,p<O.Ol and from 82.82±13.15
to 78.88±83 mmHg,p<0.03 respectively. No significant difference in plasma uric acid
level was observed after CsA reduction,p<0.06.
Conclusion: This study suggests that CsA reduction is safe and is not associated
with an increased risk of acute rejection. It also has the potential to improve allograft
function and appears to reduce cardiovascular risk factors such as hypertension and
hyperlipidemia.
Cyclosporine-Mycophenolate Mofetil-Graft survival-Chronic Nephropathy- Hyperlipidemia
329
332
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-21&slc_lang=en&sid=1
F
AHMADI
f_ahmadish@yahoo.com
20031947532846003298
20031947532846003298
Yes
Department of Nephrology, Tehran University of Medical Sciences, Imam Khomeini Hospital
M
LESSAN-PEZESHKI
20031947532846003299
20031947532846003299
No
M.R
KHATAMI
20031947532846003300
20031947532846003300
No
M
MAHDAVI-MAZDEH
20031947532846003301
20031947532846003301
No
S
MAZIAR
20031947532846003302
20031947532846003302
No
S
SEIFI
20031947532846003303
20031947532846003303
No