Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1398
11
1
gregorian
2020
2
1
34
1
online
1
fulltext
en
Assessment of intelligence quotient score in children at the age of six with suspected congenital hypothyroidism: A retrospective cohort study
Preventive Medicine & Community Health
Preventive Medicine & Community Health
Original Research
Original Research
<strong>Background: </strong>The clinical suspicion of Congenital Hypothyroidism (CH) is identified by abnormal results in the first test of Thyroid Stimulating Hormone (TSH) (5-9.9 mIU/L), and normal results in re-test (TSH<4 mIU/L). The CH has a contribution to physical and mental health. This study aimed to determine the Intelligence Quotient (IQ) score in children with suspected congenital hypothyroidism.<br>
<strong>Methods:</strong> This research is a retrospective cohort study conducted in Mashhad, Iran. The IQ scores of 1976 children at the age of 6 were considered as an outcome variable. The history of CH screening for each newborn was assessed, then all suspected CH newborns that diagnosed healthy in re-test were considered as an exposed group, the effects of this situation on IQ score was assessed using logistic regression. All analysis was performed in STATA.<br>
<strong>Results:</strong> The averages of IQ score (p<0.001), weight (p=0.024), and height (p<0.001) in the exposed group were lower than the unexposed group. The exposed group was related to those whose parental education was less or equal to 12 years (p<0.001). Similarly, the history of CH and maternal education for ≤12 years were detected as risk factors for having an IQ score of <90 in children.<br>
<strong>Conclusion:</strong> Aside from the link between parental education and clinical suspicion of CH in neonates, our findings underline the possible strong effect of CH status and maternal education for ≤12 years on reducing IQ scores in the next years of child life.
Intelligence quotient, Suspected CH newborn, Congenital hypothyroidism
797
801
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-4807-1&slc_lang=en&sid=1
Shahin
Saeidinejat
saeedish1@mums.ac.ir
200319475328460064348
200319475328460064348
Yes
1. Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Nosrat
Ghaemi Belhouri
200319475328460064349
200319475328460064349
No
2. Department of Pediatric Endocrinology and Metabolism, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Fahimhe
Attarian
attarian581@gmail.com
200319475328460064350
200319475328460064350
No
Student Research Committee, Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran