Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1397
11
1
gregorian
2019
2
1
33
1
online
1
fulltext
en
Correlation of cancer antigen 15-3 (CA15-3) serum level and bony metastases in breast cancer patients
Oncology
Oncology
Original Research
Original Research
<strong>Background: </strong>Cancer antigen 15-3 (CA15-3) is a common tumor marker and the serum level of this tumor marker is evaluated during the treatment period (periodically) in breast cancer patients. Assuming that the elevated serum levels of this tumor marker can be a potential risk, this study was conducted to determine the association between CA15-3 and bone metastasis and CA15-3 and metastasis spreading rate in breast cancer patients. <br>
<strong>Methods:</strong> In this study, 70 women with the mean of age 51.69 (10.77) years who suffered from breast cancer were studied by performing both bone scintigraphy and measuring CA15-3. Independent sample t test, Fisher’s exact test, Spearman rho correlation, and logistic regression were used for inferential section. To determine the new cross section, Roc curve and coordinates of the curve were applied. Also, significance level was set at p<0.05. Data were analyzed by SPSS 16 software.<br>
<strong>Results:</strong> There was no difference among patients in age (p=0.123). Assuming the CA15-3 (≥ 30 U/mL) as a potential risk, there was no association between CA15-3 and bone metastases (p=0.167). Based on Spearman's rank correlation coefficient, there was no significant correlation between CA15-3 and metastasis spreading rate (r=-0.07, p=0.851). Based on ROC curve and Youden's J statistic index, the new cutoff was pointed at CA15-3 ≥21.76 Unit/mL, which correlated with bone metastases (p<0.001).<br>
<strong>Conclusion:</strong> This study found a decreased cutoff point at CA15-3 (≥21.76) against 30 (routine value). Based on CA15-3 (≥21.76), there was a correlation between bone metastases and CA15-3, indicating that patients with CA15-3 (≥21.76) were most likely to experience bone metastases. <br>
<br>
Breast cancer, Bone scintigraphy, CA15-3, Bone metastases
869
874
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-4846-1&slc_lang=en&sid=1
Ashraf
Fakhari
Fakhari.a@tbzmed.ac.ir
200319475328460062226
200319475328460062226
No
Medical Radiation Sciences Research Team, & Department of Radiology, Medical School, Tabriz University of Medical Sciences, Tabriz, Iran
Esmaeil
Gharepapagh
gharepapaghe@tbzmed.ac.ir
200319475328460062227
200319475328460062227
Yes
Medical Radiation Sciences Research Team, & Department of Radiology, Medical School, Tabriz University of Medical Sciences, Tabriz, Iran
Shahram
Dabiri Oskuei
sh.dabiri1339@gmail.com
200319475328460062228
200319475328460062228
No
Medical Radiation Sciences Research Team, & Department of Radiology, Medical School, Tabriz University of Medical Sciences, Tabriz, Iran
Neda
Gilani
Gilanin@tbzmed.ac.ir
200319475328460062229
200319475328460062229
No
Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran