Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1398
11
1
gregorian
2020
2
1
34
1
online
1
fulltext
en
Association of cigarette smoking with irritable bowel syndrome: A cross-sectional study
Gastroenterology
Gastroenterology
Original Research
Original Research
<strong>Background: </strong>Irritable Bowel Syndrome (IBS) is one of the most commonly diagnosed gastrointestinal disorders, and its etiology is believed to be multifactorial. The role of smoking in the pathophysiology of IBS still remains inconclusive. Hence, we aim to investigate whether or not an association exists between smoking and IBS.<br>
<strong>Methods: </strong>A cross-sectional study was conducted in a tertiary care hospital of Karachi. A sample size of 200 smokers and 200 non-smokers was selected. A two-part self-reported questionnaire was administered to the participants and the diagnosis of IBS was based on the Rome III diagnostic criteria. All data were analyzed using the Statistical Package for the Social Sciences version 17. Statistical tests employed were Independent samples t-test, chi-square test, and binary logistic regression analysis to obtain Odds Ratio (OR) for various variables. A P-value <0.05 was considered statistically significant.<br>
<strong>Results: </strong>Overall prevalence of IBS based on Rome III criteria was 9.5% (95% CI 9.45-9.60). Smoking was significantly found to be associated with IBS (P=0.002). Binary logistic regression analysis indicated that non-smokers were more likely to have IBS (Crude OR: 3.00, 95% CI 1.23-7.30) than smokers, and females were more likely to have IBS (Crude OR: 3.73, 95% CI 1.56-7.69) than males. Age, BMI, and food groups were not found to be significantly associated with IBS.<br>
<strong> Conclusion:</strong> Our study concludes that IBS was more prevalent among non-smokers and amongst females. Further studies are required to firmly establish the role of smoking in IBS.<br>
Irritable bowel syndrome, Smoking, Risk factors, Gastrointestinal diseases, Pakistan
510
516
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-4972-1&slc_lang=en&sid=1
Khalid
Mahmood
khalid_khas1@hotmail.com
200319475328460064107
200319475328460064107
No
Department of Internal Medicine, Dr. Ruth Pfau Civil Hospital Karachi, Baba-e-Urdu Road, Karachi, Pakistan
Ramsha
Riaz
ramshariaz1028@gmail.com
200319475328460064108
200319475328460064108
No
Dow Medical College, Dow University of Health Sciences, Baba-e-Urdu Road, Karachi, Pakistan
Muhammad Salman
Ul Haq
m.salman.haq@gmail.com
200319475328460064109
200319475328460064109
Yes
Dow Medical College, Dow University of Health Sciences, Baba-e-Urdu Road, Karachi, Pakistan
Khizar
Hamid
khizar.hamid@gmail.com
200319475328460064110
200319475328460064110
No
Dow Medical College, Dow University of Health Sciences, Baba-e-Urdu Road, Karachi, Pakistan
Hassaan
Jawed
hassaanj94@hotmail.com
200319475328460064111
200319475328460064111
No
Dow Medical College, Dow University of Health Sciences, Baba-e-Urdu Road, Karachi, Pakistan