Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1398
11
1
gregorian
2020
2
1
34
1
online
1
fulltext
en
Evaluation of HBs-Ag and anti-HBc levels in serum and saliva of patients with hepatitis B
Gastroenterology and Liver Disease
Gastroenterology and Liver Disease
Original Research: Clinical Science
Original Research: Clinical Science
<strong>Background: </strong>Hepatitis B is a common infectious disease with serious complications. Health care workers (HCWs) are among the susceptible groups for Hepatitis B Virus (HBV) infection. Hepatitis B Virus is usually diagnosed through serological tests, which are invasive and expensive. Having in mind that saliva can be seen in many cases as an indicator of serological changes, in this study we aimed to assess the specificity and sensitivity of salivary HBs-Ag and anti-HBc, as the 2 diagnostic markers of HBV infection, compared to serological results of these markers.<br>
<strong>Methods:</strong> Samples were obtained from 39 individuals diagnosed with hepatitis B and 20 healthy individuals. In this study serum HBs-Ag and anti-HBc of all the patients were evaluated by their physicians in the previous week. Unstimulated whole saliva was collected and sent to laboratory for evaluating salivary HBs-Ag and anti-HBc. Specificity and sensitivity were evaluated through data analysis by SPSS software.<br>
<strong>Results:</strong> Serum was considered as a reference test and saliva as an index test. Sensitivity and specificity for oral fluid assay were measured: Sensitivity and specificity of salivary HBs-Ag were 86% and 95%, respectively, and they were 71% and 95%, respectively, for anti-HBc.<br>
<strong>Conclusion:</strong> Our results suggest that salivary tests of HBs-Ag and anti-HBc marker could have the potential to replace serological tests for these markers.
Hepatitis B, Saliva, Serum, HBs-Ag, Anti-HBc
709
711
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-4998-1&slc_lang=en&sid=1
Matine
Gharavi
lvlatine@gmail.com
200319475328460064274
200319475328460064274
Yes
Department of Oral Medicine, Faculty of Dentistry, Shahed University, Tehran, Iran
Mostafa
Esmaeili
m.esmaeili@gmail.com
200319475328460064275
200319475328460064275
No
Department of Oral Medicine, Faculty of Dentistry, Shahed University, Tehran, Iran