Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1383
8
1
gregorian
2004
11
1
18
3
online
1
fulltext
en
COMPARATIVE STUDY OF CHEMORADIATION AND NEOADJUV ANT CHEMOTHERAPY BEFORE RADICAL HYSTERECTOMY IN STAGE m - 1m BULKY CERVICAL CANCER AND WITH TUMOR DIAMETER GREATER THAN 4 CM
Gynecology & Obstetrics
Gynecology & Obstetrics
Original Research: Clinical Science
Original Research: Clinical Science
Tumor size seems to be a determinant in the prognosis of early cervical cancer.
Patients with tumor size greater than 4 cm (bulky) in diameter have worse outcome.'
The purpose of this study was to compare the efficacy of preoperative combined
chemoradiation and neoadjuvant chemotherapy (NArC) programs followed by
radical hysterectomy in stage Ib - lIb bulky cervical cancer.
From September 1999 to April 2002, 60 patients with stage Ib - IIb bulky
cervical cancer were treated with preoperative extemal beam radiotherapy to
45Gy plus weekly cisplatin 50 mg/m2 or preoperative neoadjuvant chemotherapy
by cisplatin 50 mg/m2 and vincristin 1 mg/m2 every 7-10 days, for three courses,
Surgery was perfonned 4-6 weeks after completion of the preoperative treatment.
There was no significant difference between age, stage, tumor size and
histopathological type in the two groups (p>0.05).Toxicity associated with the
two treatment methods was usually mild. In the chemoradiation group, two patients
developed vesicovaginal fistula, and four patients developed long term hydronephrosis
that needed ureteral stenting. Before surgery, complete and pmiial clinical
response had no significant difference between the two groups (p>0,05). After
surgery, lymph node and parametrial involvement had no significant difference
between the two groups (p>0.05). In the NAIC group more patients had
significant residual tumor (p=0,0 12) but residual tumor size had no significant
difference between the two groups (p>0. 05). Pathological complete response was
significantly higher in the chemoradiation group (p= 0. 004),
According to the results of this study it seems that NArC and chemoradiation
have similar effects on survival prognostic factors
Chemoradiation, neoadjuvant chemotherapy, radical hysterectomy, cervical cancer
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-53&slc_lang=en&sid=1
M
MODARES
20031947532846003420
20031947532846003420
Yes
From the Department of Gynecology & Obstetrics, Tehran Universiry of Medical Sciences, Tehran, Iran.
A
MOUSAVI
20031947532846003421
20031947532846003421
No
N
BEHTASH
20031947532846003422
20031947532846003422
No
M
GOLNAVAZ
20031947532846003423
20031947532846003423
No