en Otorhinolaryngology Otorhinolaryngology Original Research Original Research <p> <strong> Abstract </strong></p><p> <strong> Background: </strong>Over the past 20 years, the minimally invasive endoscopic approach </p><p>  has gained widespread acceptance. The study was performed to evaluate the </p><p>  diagnostic method and the success rate of endoscopically diagnosed and treated CSF </p><p>  rhinorrhea, and also investigations such as leakage site and etiologic factor. </p><p> <strong> Methods: </strong>This retrospective CSF leakage management review of patients experiencing </p><p>  CSF rhinorrhea made from 1999-2006 included data regarding leakage etiology, </p><p>  preoperative assessment, intraoperative techniques and postoperative followup. </p><p> <strong> Result: </strong>Sixty-five patients were managed endoscopically. CSF rhinorrhea etiology </p><p>  was traumatic in 30 cases, iatrogenic in 23 and spontaneous in 12. We used nasal </p><p>  endoscopy and high resolution computed tomography (HRCT) in all 65 cases while </p><p>  CT metrizamide cisternography was used in 5 specifically and magnetic resonance </p><p>  imaging for 5 others. Intrathecal fluorescein was used for intraoperative assessment </p><p>  without complications, and only one case of meningismus was noted. </p><p> <strong> Conclusion: </strong>Several imaging methods were effective in diagnosing CSF leakage </p><p>  sites. Endoscopic management and autografts were successful in repairing anterior </p><p>  skull defects in 90.76% of the cases. </p> CSF leakage, skull base defects, diagnostic tests, endoscopic diagnosis and management. 12 16 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-55&slc_lang=en&sid=1 Shabahang Mohammadi 20031947532846001546 20031947532846001546 Yes Department of Otorhinolaryngology-Head & Neck Surgery, Hazrate-e- Ahmad Daneshi 20031947532846001547 20031947532846001547 No Department of Otorhinolaryngology-Head & Neck Surgery, Hazrat-e Rasool Hospital, Iran University of Medical Sciences. Mohammad Farhadi 20031947532846001548 20031947532846001548 No Department & Research Center of Otorhinolaryngology-Head & Neck Surgery, Hazrat-e Rasool Hospital. Saleh Mohebbi 20031947532846001549 20031947532846001549 No Head and Neck Surgery, Shahid Mohammadi Hospital(Bandar Abbas).