en Medical Education Medical Education Systematic Review <strong>Background: </strong>Gamification is an effective tool used to enhance the quality of education and training, to create motivation and enthusiasm, and to maintain competitiveness in the targeted population.&nbsp; Given that, the present study is an attempt to review gamification used in the field of diabetes systematically and its effects on the target group.<br> &nbsp;&nbsp; <strong>Methods: </strong>Articles were retrieved from eight databases via an electronic advanced search. The data were imported to Endnote; and to assess the quality of the articles, PRISMA and CASP were used. Finally, according to the inclusion criteria, the appropriate articles were selected.<br> &nbsp;&nbsp; <strong>Results:</strong> This study indicates that physical activity and nutrition were the most frequent diabetic subgroups in diabetes gamification. In addition, all diabetes gamification programs were designed to educate, teach skills and make behavior improvement in diabetics.&nbsp;<br> &nbsp;&nbsp; <strong>Conclusion:</strong> Diabetes gamification have the capacity to change health behaviors among all age groups and can create an innovative, attractive and interactive learning environment accompanied by fun and engagement. Professor, Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran; Librarianship and Medical Information Science, Iran University of<br> Medical Sciences, Tehran, Iran. Gamification, Video games, Serious game, Educational game, Diabetes 1163 1177 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-4508-2&slc_lang=en&sid=1 Shadi Asadzandi shadi_asadzandi@yahoo.com 200319475328460062971 200319475328460062971 No Department of Librarianship and Medical Information Science School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran Shahram Sedghi sedghi.s@iums.ac.ir 200319475328460062972 200319475328460062972 Yes Department of Librarianship and Medical Information Science School of Health Management and Information Sciences, & Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran Shoaleh Bigdeli bigdeli.sh@iums.ac.ir 200319475328460062973 200319475328460062973 No Center for Educational Research in Medical Sciences (CERMS), Department of Medical Education, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mahnaz Sanjari mahnaz.sanjari@gmail.com 200319475328460062974 200319475328460062974 No Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, & Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran