Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1384
8
1
gregorian
2005
11
1
18
4
online
1
fulltext
en
EFFECTS OF NOVEL 2-ALKYLAMINOSUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM
Pharmacology
Pharmacology
Original Research: Clinical Science
Original Research: Clinical Science
In order to investigate the effects of dimethylamino substituent at position 2 of the
dihydropyridine nucleus on activity, starting from dialkyl l ,4-dihydro-2,6-dimethyl-4-
(l-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (5a-f) which their synthesis
and effects as calcium channel antagonist on guinea-pig ileum has been reported
previously, dialkyl l,4-dihydro-2-[2-(dimethylamino)ethyl]-6-methyl-4-(l-benzyl-2-
alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (6a-f) were synthesized.
Rabbit jejunum was used to determine the relaxant or antagonistic activity of the
test compounds. The test compounds (6c-e) inhibited the spontaneous contractile activity
dose-dependently and completely, while high-K+ contracted tissues were relaxed
partially.
2-Dimethylamino-substituted dihydropyridines, Rabbit jejunum, Calcium Channel.
361
364
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-79&slc_lang=en&sid=1
F
HADIZADEH
fhadizadeh@yahoo.com
20031947532846003533
20031947532846003533
Yes
From the Department of Medicinal Chemistry, Pharmacy Faculty, Mashhad University of Medical Sciences, P.O.Box 91775-1365, Mashhad, Iran
BF
ANARAKI-FIROOZ
20031947532846003534
20031947532846003534
No
the Biotechnology &Pharmaceutical Sciences Research Center, Postal Code 9196773117, Bu-Ali Square, Mashhad, 1ran
SIH
TAQAVI
20031947532846003535
20031947532846003535
No
the Department of Pharmacology,Jinnah Medical and Dental College, Karachi, Pakistan