Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1398
11
1
gregorian
2020
2
1
34
1
online
1
fulltext
en
Liver fat content might be an appropriate measure for estimation of cardiovascular disease risk in non-alcoholic steatohepatitis patients
Gastroenterology
Gastroenterology
Original Research
Original Research
<strong>Background: </strong>Non-alcoholic steatohepatitis (NASH) is increasing worldwide due to the metabolic syndrome epidemy. According to the current evidence, a higher cardiovascular disease risk (CVDR) is observed in NASH individuals than the general population.<br>
Objective: The relationship between liver fat content (LFC) and CVDR in a cohort of NASH patients was evaluated in this research.<br>
<strong>Methods:</strong> Consecutively selected patients with increased aminotransferase levels and fatty change in liver ultrasonography were enrolled in the study. Those with known causes of viral hepatitis, any hepatotoxic medications or alcohol consumption, autoimmune hepatitis, cigarette smoking, and ischemic heart disease were excluded from the project. The remaining was presumed to have NASH. The Framingham risk score (FRS) and LFC were calculated by means of an online calculator and a valid formula, respectively. The correlation between LFC and independent variables was measured using the Pearson correlation test. The P-value of less than 0.05 was considered significant. The statistical analysis was performed using SPSS program version 18.<br>
<strong>Results:</strong> Finally, two hundred NASH patients were included in the study. Considering diabetes mellitus as a confounder, there was a fair relationship between LFC and FRS (R=0.26 and 0.23, respectively, p<0.05) in the second and third visits. Even after adjustment for known cardiovascular risk factors, LFC was associated with increased CVDR (OR=9.181; 95% CI: 2.00-42.14, p=0.01). The cut-off value of 9.1% for LFC had a sensitivity of 92% and a specificity of 87% for discrimination of the FRS >20% and <20%.<br>
<strong>Conclusion:</strong> LFC might independently be correlated with CVDR in NASH patients. If further research confirmed this relationship, the inclusion of LFC into the FRS formula would provide an appropriate CVDR estimation tool in NASH.
Non-alcoholic fatty liver disease, Cardiovascular disease, Fatty liver, Coronary artery disease
928
933
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-811-1&slc_lang=en&sid=1
Raika
Jamali
RAIKA.JAMALI@GMAIL.COM
200319475328460064453
200319475328460064453
No
Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
Saeed
Pourhassan
spourhassan@sina.tums.ac.ir
200319475328460064454
200319475328460064454
Yes
Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Nastaran
Maghbooli
nasi_lam@yahoo.com
200319475328460064455
200319475328460064455
No
Department of Physical Medicine and Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran
Haleh
Ashraf
ha_as_ta@yahoo.com
200319475328460064456
200319475328460064456
No
Cardiac Primary Prevention Research Center, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
Amir Ali
Sohrabpoor
aasohrabpour@gmail.com
200319475328460064457
200319475328460064457
No
Digestive Diseases Research Center, Digestive Diseases Research Institute, Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran