en Psychology Psychology Systematic Review <div style="text-align: justify;"><strong>Background: </strong>According to the expansion of suicide prevention applications in recent years, the aim of this study was to review randomized controlled trials (RCTs) and pretest-posttest studies that evaluated the effectiveness of suicide prevention applications.<br> &nbsp;&nbsp; <strong>Methods:</strong> In this systematic review, we searched online databases including Pubmed, SCOPUS, Web of Science, Chocrane Database, and Google Scholar to find randomized controlled trials and pretest-posttest studies published up to Jul 18, 2019. Randomized controlled trials and pretest-posttest of efficacy self-guided telephone applications that reported any primary and secondary outcome of suicidal thoughts and behaviors were included in the review. We evaluated the articles using the CONSORT 2010 checklist.<br> &nbsp;&nbsp; <strong>Results:</strong> After screening articles, 7 studies were included in this review. Four studies focused on the effectiveness of applications on suicide thoughts and attempt, 2 on effectiveness of applications on self-injury, 4 on depression and anxiety, 1 on impulsivity, and 2 on adaptive strategies. Overall, mobile phone applications were associated with reductions in suicidal ideation scores at post intervention, and enhancement of adaptive skills; however, no evidence of reduction was reported in impulsivity after use of applications.<br> &nbsp;&nbsp; <strong>Conclusion:</strong> Despite the differences in studies, this review showed that the use of mobile applications had an overall positive effect on reducing the risk of suicide and improving performance and health of patients.<br> &nbsp;</div> Smartphone application, Effectiveness, Suicide prevention, Clinical trials 594 603 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-4370-1&slc_lang=en&sid=1 Seyed Kazem Malakouti Malakouti.k@iums.ac.ir 200319475328460064167 200319475328460064167 No Mental Health Research Centere, School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatry), Iran University of Medical Sciences, Tehran, Iran Nafee Rasouli rasouli.n@iums.ac.ir 200319475328460064168 200319475328460064168 Yes Mental Health Research Centere, School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatry), Iran University of Medical Sciences, Tehran, Iran Mohsen Rezaean moeygmr2@yahoo.co.uk 200319475328460064169 200319475328460064169 No Epidemiology and Biostatistics Department, Rafsanjan Medical School, Occupational Environmental Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Marzieh Nojomi nojomi.m@iums.ac.ir 200319475328460064170 200319475328460064170 No 3. Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Department of Community and Family Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Behrooz Ghanbari ghanbari.b@iums.ac.ir 200319475328460064171 200319475328460064171 No Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran Azita Shahraki Mohammadi Shahraki.a@iums.ac.ir 200319475328460064172 200319475328460064172 No Student Research Committee, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran