Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1400
10
1
gregorian
2022
1
1
36
1
online
1
fulltext
en
The Effect of Calorie Restriction and Intermittent Fasting on Impaired Cognitive Function in High-Fat Diet-Induced Obesity Started Post-Weaning in Male Wistar Rat
Nutrition
Nutrition
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
<strong>Background: </strong>Calorie Restriction (CR) is known as one of the most effective life-extending interventions. Therefore researchers are looking for other interventions or drugs to mimic the mentioned effects. Time-restricted feeding (TRF) has recently gained more attention recently as one of the CR mimetics. Here we evaluate and compare the effects of CR or TRF on cognitive function in young animals fed a high-fat diet (HFD).<br>
<strong>Methods:</strong> This is an experimental study that three-week-old male Wistar rats (n:52) were subjected to a control diet (n:11) or HFD (n:42). Then the HFD group was divided into 1) 30% calorie restriction (CR), 2) Night Intermittent Fasting (NIF), 3) Day Intermittent Fasting (DIF), and 4) Ad-Libitum (AL) with the standard diet for ten weeks (each of 9). An independent T-test or Mann–Whitney test was used for the first phase and in the second phase of the study, one-way analysis of variance (ANOVA), followed by Tukey post-hoc tests, or Kruskal–Wallis and post-hoc Bonferroni test were used. P-values of <0.05 were considered significant<br>
<strong>Results: </strong>Deteriorated mental function was significantly lower in HFD than CON (p= 0.041). CR was still more efficient than NIF in cognitive function in obese subjects. Post-hoc test indicated that from day 2-4, escape latency was significantly shorter in NIF and CR, which was not seen in other groups (p=0.045).<br>
<strong>Conclusion:</strong> While TRF has garnered much attention recently, here we show that CR is still more efficient in learning and memory tasks. Longer fasting times and different fasting periods are recommended to study.
Cognitive Function, Calorie Restriction, Intermittent Fasting, Circadian
97
103
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-3712-2&slc_lang=en&sid=1
Nazanin
Asghari Hanjani
nazaninhanjani_1990@yahoo.com
200319475328460068273
200319475328460068273
No
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
Negar
Zamaninour
Zamaninour.n@iums.ac.ir
200319475328460068274
200319475328460068274
No
Department of Minimally Invasive, Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran
Somayeh
Athari Nik Azam
atharisetareh@gmail.com
200319475328460068275
200319475328460068275
No
Cellular and Molecular Nutrition Department, School of Nutritional and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
Aghafatemeh
Hosseini
hosseini.f@iums.ac.ir
200319475328460068276
200319475328460068276
No
Department of Statistics and Mathematics, School of Health Management and Information Science, Iran University of Medical Sciences, Tehran, Iran
Farinaz
Nasirinezhad
nasirinezhad.f@iums.ac.ir
200319475328460068277
200319475328460068277
No
Physiology Research Center, Department of Physiology, Iran University of Medical Sciences, Teharn.Iran
MohammadReza
Vafa
vafa.m@iums.ac.ir
200319475328460068278
200319475328460068278
Yes
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran