en Health Management and Economics Health Management and Economics Original Research Original Research <strong>Background: </strong>The EuroQol five-dimensional 5 level (EQ-5D-5L) value set is not currently available for the Iranian general public, while the value set for EuroQol five-dimensional 3 level (EQ-5D-3L) is available. The present study aimed to generate an interim EQ-5D-5L value set for the context of Iran.<br> &nbsp;&nbsp; <strong>Methods:</strong> The Iranian interim EQ-5D-5L value set was generated using the crosswalk method, which maps EQ-5D-3L and EQ-5D-5L responses. The EQ-5D-3L value set has previously been estimated by Time Trade-Off (TTO) method. The interim value set obtained for EQ-5D-5L was compared with the value set of EQ-5D-3L by using measures of mean, median, and skewness.The analysis was done using STATA version 15.<br> &nbsp;&nbsp; <strong>Results:</strong> The mean and median scores of the Iranian interim value set were 0.499 and 0.451 for EQ-5D-5L and 0.455 and 0.459 for Iranian EQ-5D-3L, respectively. The range of value for both EQ-5D-3L and interim EQ-5D-5L was -0.113 to 0.919. Data skewness of EQ-5D-3L and interim EQ-5D-5L was-0.099 and -0.114, respectively. In addition, the figure of distribution of value sets for both data sets had a tail extended towards the left. The states of &ldquo;good health&rdquo;(i.e., states with value>0.8) for the EQ-5D-3L value set were proportionally more than the Iranian interim EQ-5D-5Lcrosswalk value set&nbsp; (2.47% vs. 0.448%).<br> &nbsp;&nbsp; <strong>Conclusion: </strong>An EQ-5D-5L value set was generated using the crosswalk method for the Iranian general public, and&nbsp; now researchers and policy-makers can apply it to their economic and clinical analyses. Crosswalk, Value set, EQ-5D-5L, Iran 828 832 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-3497-1&slc_lang=en&sid=1 Hosein Ameri Hamery7@yahoo.com 200319475328460064365 200319475328460064365 Yes Health Policy and Management Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Hossein Safari hossein_comely1367@yahoo.com 200319475328460064366 200319475328460064366 No Health Promotion Research Centre, Iran University of Medical Sciences, Tehran, Iran Mahmood Yousefi mahmoodyousefi80@yahoo.com 200319475328460064367 200319475328460064367 No Iranian Center of Excellence in Health Management, School of Management and Medical Informatics, Health Economics Department, Tabriz University of Medical Sciences, Tabriz, Iran Saeid Bagheri faradonbeh s.bagheri88@yahoo.com 200319475328460064368 200319475328460064368 No Health Service Management Research Center, Institute for Future Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Reza Goudarzi rgoudarzi@yahoo.com 200319475328460064369 200319475328460064369 No Health Service Management Research Center, Institute for Future Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Moslem Soofi moslemsoofi@yahoo.com 200319475328460064370 200319475328460064370 No Social Development and Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran