Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1400
10
1
gregorian
2022
1
1
36
1
online
1
fulltext
en
Assessment of the Predictive Factors Influencing the Diagnosis and Severity of Villous Atrophy in Patients with Celiac Disease and Iron Deficiency Anemia Referred for Diagnostic Endoscopy in Basrah, Iraq
Gastroenterology
Gastroenterology
Original Research: Clinical Science
Original Research: Clinical Science
<strong> </strong><strong> Background: </strong>The classic celiac disease (CD) presentation in individuals with iron deficiency anemia (IDA) has been changed given the large percentage of subtle or asymptomatic cases. The study objective was to assess the predictive factors influencing the diagnosis and severity of villous atrophy in individuals with CD and IDA referred for a diagnostic endoscopy.<br>
<strong>Methods: </strong>This was a retrospective observational, cross-sectional analysis of the medical records of 499 individuals with IDA in 2 centers in Basrah, Iraq, who referred for possible diagnosis of CD within 10 years (2006-2016). The relationship of the severity of anemia, demographic characteristics, symptomatology, and celiac serological results on the final diagnostic endoscopic evaluation was evaluated using a univariate analysis, at a P value ≤ 0.05. The study adopted the Marsh classification for celiac disease diagnosis where Marsh type 3 represents the definite celiac disease.<br>
<strong>Results:</strong> The definite diagnosis was seen in 44.5% of the cohort (n = 222), with asymptomatic cases representing 22.5% of cases (n = 50). The mean age was (27 ± 11) years, with significant association to (female gender, age ≤45 years, positive celiac serology, and severity of anemia). After adjustment of the variables, the Marsh type was significantly correlated with positive celiac serology, low hemoglobin, and presence of gastrointestinal symptoms.<br>
<strong>Conclusion:</strong> The positive celiac serology, low hemoglobin <9 g/L, and the presence of gastrointestinal symptoms are strong predictors of the severity of villous atrophy (Marsh type).
Anemia, Anti-Tissue, Celiac, Endoscopy, Gastrointestinal, Marsh, Serology, Symptoms
158
164
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-5763-1&slc_lang=en&sid=1
Samih Abed
Odhaib
samihabed@yahoo.com
200319475328460068389
200319475328460068389
Yes
Iraqi Board of Medical Specialization, American College of Physicians, Faihaa Teaching Hospital-Basrah-Iraq, Faihaa Specialized Diabetes Endocrine and Metabolism Center, Basrah, Iraq
Miaad Jassim
Mohammed
miaadjassimmohammed@gmail.com
200319475328460068390
200319475328460068390
No
Arab Board of Health Specialization (Radiology). Al-Refaee General Hospital. Thi-Qar Health Directorate, Thi Qar, Iraq
Saad Shaheen
Hamadi
saadenoor@yahoo.com
200319475328460068391
200319475328460068391
No
Professor of Internal Medicine, College of Medicine, University of Basrah, Basrah, Iraq