en Human Genetics Human Genetics Review Article Review Article <strong>Background: </strong>To quantitatively estimate the relationship between IL‐1&beta; -511C>T, &minus;31T>C, and +3954C>T polymorphisms and risk of gestational disorders.<br> &nbsp;&nbsp; <strong>Methods:</strong> In this meta-analysis, eligible publications were searched in Web of Knowledge, MEDLINE, PubMed, Scopus, and Google Scholar databases (updated April 2020), using appropriate or relevant keywords. Case-control population-based reports were included if provided with genotypic frequencies of both studied groups. Statistical analyses were performed using the MetaGenyo web tool software, where a P value less than 0.05 indicated a significant association. For the assessment of between-study variations, heterogeneity analysis was applied with the I&sup2; statistics.<br> &nbsp;&nbsp; <strong>Results:</strong> A total of thirteen studies were included. We observed a significant association between IL‐1&beta;&minus;31T>C polymorphism and reduced risk of gestational disorders under codominant CT vs. CC [OR= 0.74, CI (0.59-0.92)], and dominant CT+TT vs. CC [OR= 0.74, CI (0.60-0.91)] contrasted genetic models. The stratified analysis considering the disease type showed that the 511C>T variant, under the recessive CC vs. CT+TT model, enhanced the risk of preterm birth by 1.29 fold.<br> &nbsp;&nbsp; <strong>Conclusion:</strong> Our results failed to support an association between two IL‐1&beta; polymorphisms, 511C>T and +3954C>T, with the overall risk of gestational disorders. In contrast, the 31T>C variant reduced the incidence of such diseases. Further studies are encouraged to get more precise estimates of effect sizes. Cytokine, Interleukin, Polymorphism, Pregnancy, Meta-analysis 178 187 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-5889-1&slc_lang=en&sid=1 Mahdiyeh Harati-Sadegh m.haratisadegh@yahoo.com 200319475328460063446 200319475328460063446 No Genetic of Non-Communicable Disease Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran Saman Sargazi sgz.biomed@zaums.ac.ir 200319475328460063447 200319475328460063447 Yes Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran Hamed Taheri dr.taheri@zaums.ac.ir 200319475328460063448 200319475328460063448 No Cellular and Molecular Research Center, Resistant Tuberculosis Institute, & Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Narges Arbabi narbabi0498@gmail.com 200319475328460063449 200319475328460063449 No Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran Ramin Saravani saravaniramin@yahoo.com 200319475328460063450 200319475328460063450 No Cellular and Molecular Research Center, Resistant Tuberculosis Institute, & Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Shekoufeh Mirinejad shokufemn@gmail.com 200319475328460063451 200319475328460063451 No Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran